发育性语言障碍的皮质表面积差异。

IF 3.6 Q1 LINGUISTICS
Neurobiology of Language Pub Date : 2024-06-03 eCollection Date: 2024-01-01 DOI:10.1162/nol_a_00127
Nilgoun Bahar, Gabriel J Cler, Saloni Krishnan, Salomi S Asaridou, Harriet J Smith, Hanna E Willis, Máiréad P Healy, Kate E Watkins
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引用次数: 0

摘要

约有 7% 的儿童患有发育性语言障碍 (DLD),这是一种神经发育疾病,与不明原因的持续性语言学习困难有关。我们对 DLD 的神经生物学基础了解有限。在这里,我们使用 FreeSurfer 对 156 名年龄在 10-16 岁之间、具有不同语言能力的儿童和青少年的皮层表面积和厚度进行了研究,其中包括 54 名发育性语言障碍患者、28 名有语言障碍史但不符合发育性语言障碍标准的患者,以及 74 名年龄匹配的典型语言发育(TD)对照者。我们还使用一种基于表面的自动技术检测了 DLD 的皮层不对称性。与 TD 组相比,DLD 患者的双侧额叶下回延伸至岛叶前部、颞叶后部和枕颞叶腹侧皮层以及扣带回前部和额叶上部皮层的部分表面积较小。使用语言能力因子对整个群体进行分析后发现,语言能力与类似区域的表面积呈正相关。TD和DLD的皮质厚度以及这些皮质指标的不对称性均无差异。这项研究强调了在研究神经发育障碍的大脑基础时区分表面积和皮质厚度的重要性,并表明皮质表面积的发展对 DLD 很重要。未来需要进行纵向研究,以了解 DLD 中这些皮质差异的发展轨迹以及它们与语言成熟的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differences in Cortical Surface Area in Developmental Language Disorder.

Approximately 7% of children have developmental language disorder (DLD), a neurodevelopmental condition associated with persistent language learning difficulties without a known cause. Our understanding of the neurobiological basis of DLD is limited. Here, we used FreeSurfer to investigate cortical surface area and thickness in a large cohort of 156 children and adolescents aged 10-16 years with a range of language abilities, including 54 with DLD, 28 with a history of speech-language difficulties who did not meet criteria for DLD, and 74 age-matched controls with typical language development (TD). We also examined cortical asymmetries in DLD using an automated surface-based technique. Relative to the TD group, those with DLD showed smaller surface area bilaterally in the inferior frontal gyrus extending to the anterior insula, in the posterior temporal and ventral occipito-temporal cortex, and in portions of the anterior cingulate and superior frontal cortex. Analysis of the whole cohort using a language proficiency factor revealed that language ability correlated positively with surface area in similar regions. There were no differences in cortical thickness, nor in asymmetry of these cortical metrics between TD and DLD. This study highlights the importance of distinguishing between surface area and cortical thickness in investigating the brain basis of neurodevelopmental disorders and suggests the development of cortical surface area to be of importance to DLD. Future longitudinal studies are required to understand the developmental trajectory of these cortical differences in DLD and how they relate to language maturation.

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来源期刊
Neurobiology of Language
Neurobiology of Language Social Sciences-Linguistics and Language
CiteScore
5.90
自引率
6.20%
发文量
32
审稿时长
17 weeks
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