在确定肺肉样瘤病的生理损伤程度方面,胸部计算机断层扫描比单靠胸部 X 光检查能提供更多信息。

IF 9.5 1区 医学 Q1 CRITICAL CARE MEDICINE
Chest Pub Date : 2024-11-01 Epub Date: 2024-06-01 DOI:10.1016/j.chest.2024.04.031
Bryan S Benn, William L Lippitt, Isabel Cortopassi, G K Balasubramani, Eduardo J Mortani Barbosa, Wonder P Drake, Erica Herzog, Kevin Gibson, Edward S Chen, Laura L Koth, Carl Fuhrman, David A Lynch, Naftali Kaminski, Stephen R Wisniewski, Nichole E Carlson, Lisa A Maier
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引用次数: 0

摘要

背景:肉样瘤病的分期主要依赖于斯卡丁胸部放射摄影系统,尽管胸部 CT 在临床上的应用越来越多:研究问题:除了斯卡丁分期和人口统计学外,标准化 CT 评估是否能提供对肺功能的更多了解尚不清楚,这也是本研究的重点:我们使用了NHLBI研究中的α-1抗胰蛋白酶缺乏症和肉样瘤病基因组学研究(GRADS)肉样瘤病病例(N=351),这些病例均有Scadding分期和以标准化方式获得的胸部CT扫描。一位胸部放射科医生采用视觉评分系统对所有 CT 扫描进行评分,另一位胸部放射科医生对部分 CT 扫描进行阅片。我们比较了人口统计学特征、Scadding 分期和 CT 结果以及这些指标之间的相关性。通过回归分析确定了肺活量和 DLCO 与 CT 和 Scadding 分期之间的关系(N=318)。使用 Cohen's Kappa 评估了读者之间的一致性:结果:约有 40% 的病例 CT 特征与 Scadding 分期不一致。视觉评分评估的大多数 CT 特征与肺功能呈负相关。在调整斯卡丁分期后,FEV1 和 DLCO 的相关性仍然存在,但一些 CT 特征与 FVC 的相关性变得不显著。Scadding分期主要与FEV1相关,纳入CT特征后,Scadding分期与肺功能的相关性降低。多变量回归模型可确定解释肺功能的放射学指标,其中包括斯卡丁分期与 FEV1 和 FEV1/FVC 的关系(P解释:斯卡丁分期与 FEV1 和 FEV1/FVC 的关系不显著):除了Scadding分期外,CT特征还能解释肺功能的其他变异性,有些CT特征还能消除肺功能与Scadding分期之间的关联。CT特征/表型/终型是否有助于管理肉样瘤病患者还需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Understanding the Added Value of High-Resolution CT Beyond Chest X-Ray in Determining Extent of Physiologic Impairment.

Background: Sarcoidosis staging primarily has relied on the Scadding chest radiographic system, although chest CT imaging is finding increased clinical use.

Research question: Whether standardized chest CT scan assessment provides additional understanding of lung function beyond Scadding stage and demographics is unknown and the focus of this study.

Study design and methods: We used National Heart, Lung, and Blood Institute study Genomics Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cases of sarcoidosis (n = 351) with Scadding stage and chest CT scans obtained in a standardized manner. One chest radiologist scored all CT scans with a visual scoring system, with a subset read by another chest radiologist. We compared demographic features, Scadding stage and CT scan findings, and the correlation between these measures. Associations between spirometry and diffusing capacity of the lungs for carbon monoxide (Dlco) results and CT scan findings and Scadding stage were determined using regression analysis (n = 318). Agreement between readers was evaluated using Cohen's κ value.

Results: CT scan features were inconsistent with Scadding stage in approximately 40% of cases. Most CT scan features assessed on visual scoring were associated negatively with lung function. Associations persisted for FEV1 and Dlco when adjusting for Scadding stage, although some CT scan feature associations with FVC became insignificant. Scadding stage was associated primarily with FEV1, and inclusion of CT scan features reduced significance in association between Scadding stage and lung function. Multivariable regression modeling to identify radiologic measures explaining lung function included Scadding stage for FEV1 and FEV1 to FVC ratio (P < .05) and marginally for Dlco (P < .15). Combinations of CT scan measures accounted for Scadding stage for FVC. Correlations among Scadding stage and CT scan features were noted. Agreement between readers was poor to moderate for presence or absence of CT scan features and poor for degree and location of abnormality.

Interpretation: In this study, CT scan features explained additional variability in lung function beyond Scadding stage, with some CT scan features obviating the associations between lung function and Scadding stage. Whether CT scan features, phenotypes, or endotypes could be useful for treating patients with sarcoidosis needs more study.

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来源期刊
Chest
Chest 医学-呼吸系统
CiteScore
13.70
自引率
3.10%
发文量
3369
审稿时长
15 days
期刊介绍: At CHEST, our mission is to revolutionize patient care through the collaboration of multidisciplinary clinicians in the fields of pulmonary, critical care, and sleep medicine. We achieve this by publishing cutting-edge clinical research that addresses current challenges and brings forth future advancements. To enhance understanding in a rapidly evolving field, CHEST also features review articles, commentaries, and facilitates discussions on emerging controversies. We place great emphasis on scientific rigor, employing a rigorous peer review process, and ensuring all accepted content is published online within two weeks.
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