Samuel Fuhrimann, William Mueller, Aggrey Atuhaire, Ruth Mubeezi, Johan Ohlander, Andrew Povey, Ioannis Basinas, Martie van Tongeren, Kate Jones, Karen S Galea, Hans Kromhout
{"title":"农药职业暴露与神经行为结果。不同的原始和回忆暴露测量方法对相关性的影响。","authors":"Samuel Fuhrimann, William Mueller, Aggrey Atuhaire, Ruth Mubeezi, Johan Ohlander, Andrew Povey, Ioannis Basinas, Martie van Tongeren, Kate Jones, Karen S Galea, Hans Kromhout","doi":"10.1093/annweh/wxae025","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Several measures of occupational exposure to pesticides have been used to study associations between exposure to pesticides and neurobehavioral outcomes. This study assessed the impact of different exposure measures for glyphosate and mancozeb on the association with neurobehavioral outcomes based on original and recalled self-reported data with 246 smallholder farmers in Uganda.</p><p><strong>Methods: </strong>The association between the 6 exposure measures and 6 selected neurobehavioral test scores was investigated using linear multivariable regression models. Exposure measures included original exposure measures for the previous year in 2017: (i) application status (yes/no), (ii) number of application days, (iii) average exposure-intensity scores (EIS) of an application and (iv) number of EIS-weighted application days. Two additional measures were collected in 2019: (v) recalled application status and (vi) recalled EIS for the respective periods in 2017.</p><p><strong>Results: </strong>Recalled applicator status and EIS were between 1.2 and 1.4 times more frequent and higher for both pesticides than the original application status and EIS. Adverse associations between the different original measures of exposure to glyphosate and 4 neurobehavioral tests were observed. Glyphosate exposure based on recalled information and all mancozeb exposure measures were not associated with the neurobehavioral outcomes.</p><p><strong>Conclusions: </strong>The relation between the different original self-reported glyphosate exposure measures and neurobehavioral test scores appeared to be robust. When based on recalled exposure measures, associations observed with the original exposure measures were no longer present. Therefore, future epidemiological studies on self-reported exposure should critically evaluate the potential bias towards the null in observed exposure-response associations.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"657-664"},"PeriodicalIF":1.8000,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229323/pdf/","citationCount":"0","resultStr":"{\"title\":\"Occupational exposure to pesticides and neurobehavioral outcomes. Impact of different original and recalled exposure measures on the associations.\",\"authors\":\"Samuel Fuhrimann, William Mueller, Aggrey Atuhaire, Ruth Mubeezi, Johan Ohlander, Andrew Povey, Ioannis Basinas, Martie van Tongeren, Kate Jones, Karen S Galea, Hans Kromhout\",\"doi\":\"10.1093/annweh/wxae025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Several measures of occupational exposure to pesticides have been used to study associations between exposure to pesticides and neurobehavioral outcomes. This study assessed the impact of different exposure measures for glyphosate and mancozeb on the association with neurobehavioral outcomes based on original and recalled self-reported data with 246 smallholder farmers in Uganda.</p><p><strong>Methods: </strong>The association between the 6 exposure measures and 6 selected neurobehavioral test scores was investigated using linear multivariable regression models. Exposure measures included original exposure measures for the previous year in 2017: (i) application status (yes/no), (ii) number of application days, (iii) average exposure-intensity scores (EIS) of an application and (iv) number of EIS-weighted application days. Two additional measures were collected in 2019: (v) recalled application status and (vi) recalled EIS for the respective periods in 2017.</p><p><strong>Results: </strong>Recalled applicator status and EIS were between 1.2 and 1.4 times more frequent and higher for both pesticides than the original application status and EIS. Adverse associations between the different original measures of exposure to glyphosate and 4 neurobehavioral tests were observed. Glyphosate exposure based on recalled information and all mancozeb exposure measures were not associated with the neurobehavioral outcomes.</p><p><strong>Conclusions: </strong>The relation between the different original self-reported glyphosate exposure measures and neurobehavioral test scores appeared to be robust. When based on recalled exposure measures, associations observed with the original exposure measures were no longer present. Therefore, future epidemiological studies on self-reported exposure should critically evaluate the potential bias towards the null in observed exposure-response associations.</p>\",\"PeriodicalId\":8362,\"journal\":{\"name\":\"Annals Of Work Exposures and Health\",\"volume\":\" \",\"pages\":\"657-664\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229323/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals Of Work Exposures and Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/annweh/wxae025\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals Of Work Exposures and Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/annweh/wxae025","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
摘要
背景：研究农药职业暴露与神经行为结果之间的关系时，使用了多种农药职业暴露测量方法。本研究根据乌干达 246 名小农户的原始数据和回忆性自我报告数据，评估了草甘膦和代森锰锌不同暴露测量方法对神经行为结果相关性的影响：采用线性多变量回归模型研究了 6 种暴露测量与 6 种选定的神经行为测试得分之间的关系。暴露测量包括 2017 年上一年的原始暴露测量：(i) 施用状态（是/否），(ii) 施用天数，(iii) 施用的平均暴露强度分数（EIS），(iv) EIS 加权施用天数。2019 年还收集了两项额外的测量数据：(v) 2017 年相应时期的召回施药状态和 (vi) 召回的 EIS：与原始施药状态和 EIS 相比，两种农药的召回施药状态和 EIS 的频率和数量均高出 1.2 至 1.4 倍。观察到草甘膦不同原始暴露量与 4 项神经行为测试之间存在不利关联。根据回忆信息得出的草甘膦暴露量和所有曼耕灵暴露量与神经行为结果无关：不同的原始自我报告草甘膦暴露量与神经行为测试得分之间的关系似乎是稳健的。当基于回顾性暴露测量时，与原始暴露测量之间的关系不再存在。因此，今后关于自我报告接触情况的流行病学研究应严格评估观察到的接触-反应关联中可能存在的偏差。
Occupational exposure to pesticides and neurobehavioral outcomes. Impact of different original and recalled exposure measures on the associations.
Background: Several measures of occupational exposure to pesticides have been used to study associations between exposure to pesticides and neurobehavioral outcomes. This study assessed the impact of different exposure measures for glyphosate and mancozeb on the association with neurobehavioral outcomes based on original and recalled self-reported data with 246 smallholder farmers in Uganda.
Methods: The association between the 6 exposure measures and 6 selected neurobehavioral test scores was investigated using linear multivariable regression models. Exposure measures included original exposure measures for the previous year in 2017: (i) application status (yes/no), (ii) number of application days, (iii) average exposure-intensity scores (EIS) of an application and (iv) number of EIS-weighted application days. Two additional measures were collected in 2019: (v) recalled application status and (vi) recalled EIS for the respective periods in 2017.
Results: Recalled applicator status and EIS were between 1.2 and 1.4 times more frequent and higher for both pesticides than the original application status and EIS. Adverse associations between the different original measures of exposure to glyphosate and 4 neurobehavioral tests were observed. Glyphosate exposure based on recalled information and all mancozeb exposure measures were not associated with the neurobehavioral outcomes.
Conclusions: The relation between the different original self-reported glyphosate exposure measures and neurobehavioral test scores appeared to be robust. When based on recalled exposure measures, associations observed with the original exposure measures were no longer present. Therefore, future epidemiological studies on self-reported exposure should critically evaluate the potential bias towards the null in observed exposure-response associations.
期刊介绍：
About the Journal
Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?"
We are interested in high quality scientific research addressing:
the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures;
the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities;
populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers;
the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems;
policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities;
methodologies and mechanisms that underlie the quantification and/or control of exposure and risk.
There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
