用于治疗乳腺癌的基于脂质纳米粒子的 RNA 疗法。

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Drug Delivery and Translational Research Pub Date : 2024-10-01 Epub Date: 2024-06-03 DOI:10.1007/s13346-024-01638-2
Luigia Serpico, Yuewen Zhu, Renata Faria Maia, Sumedha Sumedha, Mohammad-Ali Shahbazi, Hélder A Santos
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引用次数: 0

摘要

乳腺癌(BC)是女性中最常见的癌症,是全球医疗保健的主要负担。乳腺癌是一种复杂的异质性疾病,化疗和放疗等现有疗法往往无法提供有效的解决方案。这些疗法无法降低癌症复发的风险,而且会产生严重的副作用,进而影响患者的治疗效果。在过去十年中,人们提出了几种策略来克服这些局限性。其中,基于 RNA 的技术已在各种临床应用中展示了其潜力,尤其是在癌症治疗中。然而,RNA疗法仍受到一系列关键问题的限制,如脱靶效应和在循环中稳定性差。因此,人们一直在研究新的方法,以提高基于 RNA 的制剂的靶向性和生物利用度,从而达到适当的治疗效果。脂质纳米颗粒(LNPs)在很大程度上已被证明是核酸和 RNA 的有利载体。本视角探讨了基于 RNA 的技术的最新进展,重点是 LNPs 作为有效纳米载体在 BC 治疗中的应用及其临床应用的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Lipid nanoparticles-based RNA therapies for breast cancer treatment.

Lipid nanoparticles-based RNA therapies for breast cancer treatment.

Breast cancer (BC) prevails as a major burden on global healthcare, being the most prevalent form of cancer among women. BC is a complex and heterogeneous disease, and current therapies, such as chemotherapy and radiotherapy, frequently fall short in providing effective solutions. These treatments fail to mitigate the risk of cancer recurrence and cause severe side effects that, in turn, compromise therapeutic responses in patients. Over the last decade, several strategies have been proposed to overcome these limitations. Among them, RNA-based technologies have demonstrated their potential across various clinical applications, notably in cancer therapy. However, RNA therapies are still limited by a series of critical issues like off-target effect and poor stability in circulation. Thus, novel approaches have been investigated to improve the targeting and bioavailability of RNA-based formulations to achieve an appropriate therapeutic outcome. Lipid nanoparticles (LNPs) have been largely proven to be an advantageous carrier for nucleic acids and RNA. This perspective explores the most recent advances on RNA-based technology with an emphasis on LNPs' utilization as effective nanocarriers in BC therapy and most recent progresses in their clinical applications.

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来源期刊
Drug Delivery and Translational Research
Drug Delivery and Translational Research MEDICINE, RESEARCH & EXPERIMENTALPHARMACOL-PHARMACOLOGY & PHARMACY
CiteScore
11.70
自引率
1.90%
发文量
160
期刊介绍: The journal provides a unique forum for scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. Rationally developed, effective delivery systems can potentially affect clinical outcome in different disease conditions. Research focused on the following areas of translational drug delivery research will be considered for publication in the journal. Designing and developing novel drug delivery systems, with a focus on their application to disease conditions; Preclinical and clinical data related to drug delivery systems; Drug distribution, pharmacokinetics, clearance, with drug delivery systems as compared to traditional dosing to demonstrate beneficial outcomes Short-term and long-term biocompatibility of drug delivery systems, host response; Biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering; Image-guided drug therapy, Nanomedicine; Devices for drug delivery and drug/device combination products. In addition to original full-length papers, communications, and reviews, the journal includes editorials, reports of future meetings, research highlights, and announcements pertaining to the activities of the Controlled Release Society.
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