青蒿素草药组合突破口：驾驭疟疾治疗的双刃剑。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-19 DOI:10.1080/14786419.2024.2358524

Gokul Sudhakaran

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引用次数: 0

摘要

青蒿素类复方疗法（ACTs）疗效好、耐受性强，改变了疟疾的治疗方法。然而，新出现的抗药性危及其长期疗效。青蒿素综合疗法能够针对寄生虫的多个阶段，从而降低了抗药性风险，但重症疟疾病例可能需要额外的干预措施。将青蒿素综合疗法与辅助疗法相结合的研究显示了前景，但最佳治疗方案仍不明确。严密的抗药性监测和创新方法对于维持 ACT 的疗效至关重要。我们强调了青蒿素综合疗法的益处、局限性和潜在的协同作用，强调迫切需要采取综合战略来应对疟疾不断变化的挑战。

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Artemisinin herbal combo breakers: navigating malaria treatment’s double-edged sword

Artemisinin-based combination therapies (ACTs) have transformed malaria treatment, boasting high efficacy and tolerability. However, emerging resistance jeopardises their long-term effectiveness. ACTs’ ability to target multiple parasite stages mitigates resistance risks, but severe malaria cases may require additional interventions. Research on combining ACTs with adjunctive therapies shows promise, but optimal regimens remain unclear. Vigilant resistance monitoring and innovative approaches are crucial to sustaining ACT efficacy. We highlight the ACTs’ benefits, limitations, and potential synergies, emphasising the urgent need for comprehensive strategies to combat malaria’s evolving challenges.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.