由二硫桥介导的环糊精接枝氧化还原反应水凝胶用于调节药物输送。

IF 1.8 4区 化学 Q3 POLYMER SCIENCE
Designed Monomers and Polymers Pub Date : 2024-05-30 eCollection Date: 2024-01-01 DOI:10.1080/15685551.2024.2358581
Xin Xu, Jinku Xu, Zeyuan Sun, Derkach Tetiana
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引用次数: 0

摘要

本文合成了一种以二硫键为介导的新型单甲基丙烯酸酯化β-环糊精(β-CD)单体,然后在少量交联剂存在下与HEMA单体热共聚,制备出氧化还原反应型水凝胶,用于调节药物输送。傅立叶变换红外光谱、1H NMR、13C NMR 光谱证实了单体的结构。通过 1H NMR(0.987)和元素分析(0.937)计算,接枝到 β-CD 上的可聚合甲基丙烯酸酯基团的取代度约为 1。单甲基丙烯酸酯化的 β-CD 单体能很好地与甲基丙烯酸 2-羟乙基酯(HEMA)单体共聚,凝胶率超过 80%。水凝胶的细胞毒性较低,单甲基丙烯酸酯化β-CD单体在水凝胶中的共聚增加了水凝胶的平衡膨胀度(ESD)和拉伸强度,但透光率略有下降。药物负载量和释放速率与 β-CD 含量有关。与纯 pHEMA 水凝胶相比,β-CD 含量高(13.83 wt%)的水凝胶的葛根素(PUE)和姜黄素(CUR)负载量分别增加了 1.8 倍和 8.5 倍。掺入β-CD后,药物释放持续时间延长,尤其是姜黄素的释放时间从纯pHEMA水凝胶的5小时延长到24小时以上(释放率为80%)。水凝胶对还原型谷胱甘肽(GSH)高度敏感,3 mM 的低浓度 GSH 可显著加快药物释放速度。β-CD含量越高,水凝胶对GSH越敏感,药物释放速度越快。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cyclodextrin-grafted redox-responsive hydrogel mediated by disulfide bridges for regulated drug delivery.

In this paper, a novel mono-methacrylated β-cyclodextrin (β-CD) monomer mediated by disulfide bond was synthesized, and then thermal copolymerized with HEMA monomer in the presence of a little crosslinker to prepare redox-responsive hydrogel for regulated drug delivery. The structure of the monomer was confirmed by FTIR, 1H NMR, 13C NMR spectroscopy. The substitution degree of polymerizable methacrylated group grafted onto β-CD was about 1 by calculating by1H NMR (0.987) and element analysis (0.937). The mono-methacrylated β-CD monomer can well copolymerize with 2-hydroxyethyl methacrylate (HEMA) monomer with gel fraction over 80%. The hydrogel shows low cytotoxicity, and copolymerization of the mono-methacrylated β-CD monomer in the hydrogels increases its equilibrium swelling degree (ESD) and tensile strength, while its transmittance slightly decreases. Drug loading and release rate are dependent on the β-CD content. The hydrogel with high β-CD content of 13.83 wt% shows 1.8 and 8.5 folds puerarin (PUE) and curcumin (CUR) loading than pure pHEMA hydrogel, respectively. The incorporation of β-CD sustained drug release, especially CUR release was prolonged more than 24 h from 5 h of pure pHEMA hydrogel (80% release). The hydrogels are highly sensitive to reduced glutathione (GSH), and low concentration of GSH of 3 mM can significantly accelerate drug release rate. The higher of β-CD content, the more sensitive the hydrogels to GSH, resulting in rapider drug release rate.

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来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
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