作为人类癌症预后因素的 Runx2

IF 1.5 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Jennifer Toner, Jonathan Gordon, Haley Greenyer, Peter Kaufman, Janet Stein, Gary Stein, Jane Lian
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引用次数: 0

摘要

RUNX2 转录因子是成骨细胞系细胞和骨形成过程中必不可少的转录调节因子。Runx2在乳腺、前列腺和肺部等其他组织中的表达与肿瘤发生、癌症进展和转移有关。在本研究中,我们试图利用泛癌症分析策略确定 Runx2 在其他肿瘤中的参与程度。我们通过查询公开的多参数临床数据,将人类癌症中 RUNX2 的表达与临床病理参数联系起来。我们的分析表明,RUNX2表达或功能的改变与来自不同组织的几种癌症类型有关。我们发现,3 种肿瘤类型与 RUNX2 表达增加有关,而 RUNX2 表达减少则与其他 4 种癌症类型有关。我们对 RUNX2 的泛癌症分析揭示了我们使用的每个泛癌症数据库中发现的 RUNX2 对不同癌症调控的许多其他发现。在特定类型癌症的发展过程中,我们观察到 RUNX2 的上调和下调都会促进不同类型癌症的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Runx2 as a Prognostic Factor in Human Cancers
The RUNX2 transcription factor was discovered as an essential transcriptional regulator for commitment to osteoblast lineage cells and bone formation. Expression of Runx2 in other tissues, such as breast, prostate and lung, has been linked to oncogenesis, cancer progression and metastasis. In this study, we sought to determine the extent of Runx2 involvement in other tumors using a pan–cancer analysis strategy. We correlated RUNX2 expression and clinical-pathological parameters in human cancers by interrogating using publicly available multiparameter clinical data. Our analysis demonstrated that altered RUNX2 expression or function is associated with several cancer types from different tissues. We identified that 3 tumor types were associated with increased RUNX2 expression and decreased expression of RUNX2 is associated with 4 other cancer types. Our pan-cancer analysis for RUNX2 revealed numerous other discoveries for RUNX2 regulation of different cancers identified in each of the pan-cancer databases we used. Both up and down regulation of RUNX2 was observed during progression of specific types of cancers in promoting the distinct types of cancers.
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来源期刊
Critical Reviews in Eukaryotic Gene Expression
Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物
CiteScore
2.70
自引率
0.00%
发文量
67
审稿时长
1 months
期刊介绍: Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.
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