肠道微生物群对睡眠质量和原发性肝癌的调解/调节作用:孟德尔随机和病例对照研究

IF 3 2区 医学 Q2 CLINICAL NEUROLOGY
Yi Yang, Jingxian Wang, Qing Su, Jinhuan Yang, Zhiyuan Bo, Chongming Zheng, Yitong Xie, Kaiwen Chen, Juejin Wang, Gang Chen, Yi Wang
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引用次数: 0

摘要

背景:原发性肝癌(PLC)是一种致命的恶性肿瘤:原发性肝癌(PLC)是一种致命的恶性肿瘤,睡眠质量和肠道微生物群与原发性肝癌有关。然而,睡眠质量影响原发性肝癌的机制尚不清楚。本研究旨在探讨肠道微生物群对睡眠质量和PLC发生的中介/调节作用:方法:通过孟德尔随机化(Mendelian randomization,MR)分析检测睡眠质量与PLC发生的因果关系,分析数据包括305359名个体(芬兰数据库)和456348名参与者(英国生物库)。孟德尔随机分析的主要方法是反方差加权分析。通过对254名PLC患者和193名良性肝病患者的病例对照研究进行中介/调节效应分析,发现了肠道微生物群的中介/调节效应。研究还通过匹兹堡睡眠质量指数(PSQI)评估了患者的睡眠质量:结果:通过MR分析(P = 0.026),睡眠质量差可能导致肝硬化。病例对照研究发现,放线菌对 PSQI 评分、自我睡眠质量和 PLC 发生率之间的关系具有中介作用(P = 0.048,P = 0.046)。放线菌和双歧杆菌可抑制因夜间睡眠时间短而导致的 PLC 的发生(P = 0.021,P = 0.022)。绿脓杆菌可削弱白天功能障碍对 PLC 的影响(P = 0.033)。蔷薇可调节夜间失眠和睡眠质量差对PLC的影响(P = 0.009,P = 0.017):结论:睡眠质量差与 PLC 有关。肠道微生物群对睡眠质量差和 PLC 的发生具有调解/调节作用,这为预防 PLC 提供了一个富有洞察力的思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Mediation/Moderation Effects of Gut Microbiota on Sleep Quality and Primary Liver Cancer: A Mendelian Randomization and Case–Control Study
Background: Primary liver cancer (PLC) is a fatal malignancy, sleep quality and gut microbiota were shown to be associated with PLC. However, the mechanism of how sleep quality affects PLC is unclear. This study aims to investigate the mediation/moderation effects of gut microbiota on sleep quality and the occurrence of PLC.
Methods: The causality of sleep quality and the occurrence of PLC was detected through the Mendelian randomization (MR) analysis based on the data including 305,359 individuals (Finland Database) and 456,348 participants (UK Biobank). The primary method used for MR analysis was inverse-variance weighted analysis. Gut microbiota’ mediation/moderation effects were uncovered in the case–control study including 254 patients with PLC and 193 people with benign liver diseases through the mediation/moderation effect analyses. People’s sleep quality was evaluated through the Pittsburgh sleep quality index (PSQI).
Results: Poor sleep quality could lead to PLC through the MR analysis (P = 0.026). The case–control study uncovered that Actinobacteria had mediation effects on the relationship between PSQI score, self-sleep quality, and the occurrence of PLC (P = 0.048, P = 0.046). Actinobacteria and Bifidobacterium could inhibit the development of PLC caused by short night sleep duration (P = 0.021, P = 0.022). Erysipelotrichales could weaken the influence of daytime dysfunction on PLC (P = 0.033). Roseburia modulated the contribution of nocturnal insomnia and poor sleep quality to PLC (P = 0.009, P = 0.017).
Conclusion: Poor sleep quality was associated with PLC. Gut microbiota’ mediation/moderation effects on poor sleep quality and the occurrence of PLC prompted an insightful idea for the prevention of PLC.

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来源期刊
Nature and Science of Sleep
Nature and Science of Sleep Neuroscience-Behavioral Neuroscience
CiteScore
5.70
自引率
5.90%
发文量
245
审稿时长
16 weeks
期刊介绍: Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.
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