稳态和炎症中巨噬细胞的代谢适应和功能活动

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Taisiya R. Yurakova, Ekaterina A. Gorshkova, Maxim A. Nosenko, Marina S. Drutskaya
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引用次数: 0

摘要

摘要 近年来,细胞代谢在免疫中的作用成为许多研究的焦点。这些过程是维持组织完整性和平衡的基础,也是免疫反应,尤其是炎症反应不可或缺的一部分。代谢适应不仅确保免疫反应的能量供应,还通过控制转录和转录后程序影响免疫细胞的功能。研究免疫细胞的新陈代谢有助于寻找新的治疗方法,尤其是针对代谢紊乱的治疗方法。巨噬细胞是先天性免疫细胞,具有高度功能可塑性,在体内平衡和炎症中发挥着关键作用。根据表型和来源的不同,它们既可以发挥各种调节功能,也可以促进炎症状态,从而加重病理状况。此外,它们对特定组织微环境的适应也会影响免疫反应的强度和类型。这篇综述探讨了巨噬细胞代谢重编程对这些细胞的功能活性及其极化的影响。特别讨论了髓细胞的免疫代谢适应在组织稳态以及炎症和代谢性疾病的各种病理过程中的作用。最后,作为一种潜在的治疗方法,对巨噬细胞代谢相关机制的调节进行了回顾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Metabolic Adaptations and Functional Activity of Macrophages in Homeostasis and Inflammation

Metabolic Adaptations and Functional Activity of Macrophages in Homeostasis and Inflammation

In recent years, the role of cellular metabolism in immunity has come into the focus of many studies. These processes form a basis for the maintenance of tissue integrity and homeostasis, as well as represent an integral part of the immune response, in particular, inflammation. Metabolic adaptations not only ensure energy supply for immune response, but also affect the functions of immune cells by controlling transcriptional and post-transcriptional programs. Studying the immune cell metabolism facilitates the search for new treatment approaches, especially for metabolic disorders. Macrophages, innate immune cells, are characterized by a high functional plasticity and play a key role in homeostasis and inflammation. Depending on the phenotype and origin, they can either perform various regulatory functions or promote inflammation state, thus exacerbating the pathological condition. Furthermore, their adaptations to the tissue-specific microenvironment influence the intensity and type of immune response. The review examines the effect of metabolic reprogramming in macrophages on the functional activity of these cells and their polarization. The role of immunometabolic adaptations of myeloid cells in tissue homeostasis and in various pathological processes in the context of inflammatory and metabolic diseases is specifically discussed. Finally, modulation of the macrophage metabolism-related mechanisms reviewed as a potential therapeutic approach.

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来源期刊
Biochemistry (Moscow)
Biochemistry (Moscow) 生物-生化与分子生物学
CiteScore
4.70
自引率
3.60%
发文量
139
审稿时长
2 months
期刊介绍: Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
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