逆向遗传学在多功能细胞因子肿瘤坏死因子免疫生物学中的应用

IF 2.3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow) Pub Date : 2024-05-31 DOI:10.1134/s0006297924050067

Sergey A. Nedospasov, Andrei A. Kruglov, Alexei V. Tumanov, Marina S. Drutskaya, Irina V. Astrakhantseva, Dmitry V. Kuprash

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引用次数: 0

摘要

摘要肿瘤坏死因子（TNF）是多种细胞因子之一，是负责免疫系统细胞间交流的蛋白质分子。TNF 因其在实验系统中惊人的抗肿瘤效果而被发现并被冠以其美名，但其在整个机体中的主要生理功能却与保护机体免受肿瘤侵袭完全无关。本短文将讨论早期基因组编辑技术产生的 "人造 "小鼠模型，这些模型使我们能够确定 TNF 在健康和某些疾病中的真正功能，并揭示改善 TNF 依赖性疾病治疗的潜在策略。

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Reverse Genetics Applied to Immunobiology of Tumor Necrosis Factor, a Multifunctional Cytokine

Abstract

Tumor necrosis factor (TNF) is one of many cytokines – protein molecules responsible for communication between the cells of immune system. TNF was discovered and given its grand name because of its striking antitumor effects in experimental systems, but its main physiological functions in the context of whole organism turned out to be completely unrelated to protection against tumors. This short review discusses “man-made” mouse models generated by early genome-editing technologies, which enabled us to establish true functions of TNF in health and certain diseases as well as to unravel potential strategies for improving therapy of TNF-dependent diseases.

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来源期刊

Biochemistry (Moscow) 生物-生化与分子生物学

CiteScore

4.70

自引率

3.60%

发文量

139

审稿时长

2 months

期刊介绍： Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).