基于肽的诱导信号蛋白相互作用抑制剂：现状与前景

IF 2.3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow) Pub Date : 2024-05-31 DOI:10.1134/S000629792405002X

Vladimir Y. Toshchakov

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引用次数: 0

摘要

摘要细胞受体激活后形成瞬时蛋白复合物是细胞对外界刺激做出反应的常见机制。本文介绍了多肽抑制剂阻断信号蛋白相互作用的概念，并介绍了迄今为止在开发信号抑制剂方面取得的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Peptide-Based Inhibitors of the Induced Signaling Protein Interactions: Current State and Prospects

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Peptide-Based Inhibitors of the Induced Signaling Protein Interactions: Current State and Prospects

Formation of the transient protein complexes in response to activation of cellular receptors is a common mechanism by which cells respond to external stimuli. This article presents the concept of blocking interactions of signaling proteins by the peptide inhibitors, and describes the progress achieved to date in the development of signaling inhibitors that act by blocking the signal-dependent protein interactions.

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来源期刊

Biochemistry (Moscow) 生物-生化与分子生物学

CiteScore

4.70

自引率

3.60%

发文量

139

审稿时长

2 months

期刊介绍： Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).