破伤风--病例报告凸显诊断和治疗的挑战。

IF 2.4 Q3 INFECTIOUS DISEASES
Menno Boer, Martijn de Voogd, Nicolasine Diana Niemeijer, Lonneke van Hoeven
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引用次数: 0

摘要

由于 20 世纪中期疫苗接种计划的成功发展,破伤风已成为一种越来越罕见的传染病。在资源丰富的国家,受影响的主要是未接种疫苗或部分接种疫苗的高危人群,而在资源有限的国家,破伤风仍很流行。发达国家破伤风发病率的下降阻碍了评估破伤风感染最佳治疗方法的临床试验。目前的指导方针是基于少量的研究和病例报告。迄今为止,这些研究显示了使用苯二氮卓、硫酸镁和巴氯芬治疗破伤风感染的潜在益处。此外,还有几种治疗方法被证明有助于稳定和支持破伤风患者。然而,每种治疗方法都有其局限性,从负面副作用到后勤挑战,尤其是在发展中国家。因此,我们需要更多的知识来评估每种治疗方法的最佳应用,并进一步优化患者护理。在破伤风仍然流行且资源有限的国家,这些知识有助于减轻疾病负担,尽管接种疫苗是实现这一目标的最有效方法。本病例报告描述了对一名荷兰破伤风感染患者的治疗,并说明了苯二氮卓类药物的作用以及治疗破伤风患者的其他关键方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tetanus- a case report highlighting the challenges in diagnosis and treatment.

Tetanus has become an increasingly rare infectious disease due to the development of successful vaccination programs in the mid-20th century. In resource-rich countries, mainly unvaccinated or partly vaccinated risk groups are affected, whereas tetanus still remains prevalent in resource-limited countries. The decreasing incidence in developed countries has hindered clinical trials evaluating the best treatment modalities for tetanus infections. Current guidelines are based on a small number of studies and case reports. So far, these studies have shown potential benefits of treating tetanus infections with benzodiazepines, magnesium sulfate and baclofen. Additionally, several treatments have been shown to be useful in stabilizing and supporting patients with tetanus. However, each treatment modality has limitations, from negative side effects to logistical challenges, especially in developing countries. Therefore, further knowledge is required to evaluate the best use of each treatment and to further optimize patient care. This knowledge can contribute to the reduction of the burden of disease in countries where tetanus remains prevalent and where resources are limited, though vaccination is the most effective method to achieve this. This case report describes the treatment of a Dutch patient with tetanus infection and illustrates the role of benzodiazepines as well as other key aspects of treating patients with tetanus.

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来源期刊
CiteScore
5.20
自引率
0.00%
发文量
25
审稿时长
17 weeks
期刊介绍: Tropical Diseases, Travel Medicine and Vaccines is an open access journal that considers basic, translational and applied research, as well as reviews and commentary, related to the prevention and management of healthcare and diseases in international travelers. Given the changes in demographic trends of travelers globally, as well as the epidemiological transitions which many countries are experiencing, the journal considers non-infectious problems including chronic disease among target populations of interest as well as infectious diseases.
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