住院急性呼吸道感染研究中日本成人呼吸道合胞病毒、人类偏肺病毒和流感病毒感染的负担。

IF 2.4 Q2 RESPIRATORY SYSTEM
Masaharu Shinkai , Shinichiro Ota , Nobuhisa Ishikawa , Takuya Tanimoto , Hiroki Suzuki , Shuichi Abe , Yannick Vandendijck , Yoshikazu Nakayama , Yoko Murata
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引用次数: 0

摘要

背景:呼吸道合胞病毒(RSV)、人类偏肺病毒(hMPV)和流感病毒是成人急性呼吸道感染(ARTI)的罪魁祸首。我们评估了因急性呼吸道感染住院的日本成人中 RSV、hMPV 和流感病毒感染的临床负担:住院急性呼吸道感染(HARTI)研究是一项跨国前瞻性队列研究,研究对象是2017-2019年流行季节的成人ARTI患者。日本的研究从2018年9月开始招募,一直持续到2019年10月。ARTI的临床诊断和患者住院治疗的决定均根据当地标准护理实践做出。病毒检测通过反转录聚合酶链反应进行:在此期间,日本研究机构的 173 名因 ARTI 住院的成人中,分别有 7 人(4.0%)、9 人(5.2%)和 11 人(6.4%)流感病毒、RSV 和 hMPV 阳性。RSV流行季节为2018年10月至2019年1月,流感流行季节为2018年12月至2019年4月。两名 RSV 患者和一名 hMPV 患者需要入住重症监护室,而流感患者则无一需要入住重症监护室。与流感患者相比,RSV 和 hMPV 患者在出院后 1、2 和 3 个月内使用抗生素、支气管扩张剂和吸入性皮质类固醇的比例较高,但也有少数例外:这些发现强调了临床上高度怀疑因急性呼吸道感染住院的成人感染 RSV 和 hMPV 的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Burden of respiratory syncytial virus, human metapneumovirus and influenza virus infections in Japanese adults in the Hospitalized Acute Respiratory Tract Infection study

Background

Respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and influenza virus are responsible for acute respiratory tract infections (ARTIs) in adults. We assessed the clinical burden of RSV, hMPV and influenza virus infection among Japanese adults hospitalized with ARTIs.

Methods

The Hospitalized Acute Respiratory Tract Infection (HARTI) study was a multinational, prospective cohort study in adults with ARTIs across the 2017–2019 epidemic seasons. Enrolment in Japan began in Sept 2018 and ran until Oct 2019. The clinical diagnosis of ARTI and the decision to hospitalize the patient were made according to local standard of care practices. Viral testing was performed by reverse transcription polymerase chain reaction.

Results

Of the 173 adults hospitalized with ARTI during this period at the Japan sites, 7 (4.0%), 9 (5.2%), and 11 (6.4%) were positive for influenza virus, RSV, and hMPV, respectively. RSV season was observed from Oct 2018 to Jan 2019, followed by influenza from Dec 2018 to Apr 2019. hMPV was detected across both the RSV and influenza seasons. Two patients with RSV and 1 patient with hMPV required ICU admission whereas none with influenza. Use of antibiotics, bronchodilators and inhaled corticosteroids was high amongst patients with RSV and hMPV at 1, 2, and 3 months’ post-discharge compared with patients with influenza, with few exceptions.

Conclusion

These findings highlight the need for a high degree of clinical suspicion for RSV and hMPV infection in adults hospitalized with ARTIs.

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来源期刊
Respiratory investigation
Respiratory investigation RESPIRATORY SYSTEM-
CiteScore
4.90
自引率
6.50%
发文量
114
审稿时长
64 days
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