具有更强抗菌活性的蜂蜜混合牙科植入物的合成与表征。

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Hina Zahid, Sumbul Shamim, Muhammad Kawish, Rukesh Maharjan, Muhammad Raza Shah
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引用次数: 0

摘要

由于具有良好的口腔康复和重建能力,种植牙通常被用作牙齿替换工具。人们希望通过促进哺乳动物细胞的活性和防止细菌活动,成功地为天然牙齿进行植牙治疗,改善骨结合。蜂蜜具有潜在的抗菌和抑菌作用,特别是在烧伤和伤口愈合方面。本研究使用不同浓度的蜂蜜合成了基于蜂蜜的银纳米粒子。使用紫外光谱对合成的 HNY-AgNPs、MSN 和 HNY-AgMSN 进行了表面等离子体共振表征,使用 Zetasizer 进行了水动力学直径表征,使用原子力显微镜进行了形态学表征。使用原子力显微镜观察形态。此外,还使用分辨率为 4cm-1 的傅立叶变换红外光谱对表面官能团进行了表征。在 3000µg/mL 的浓度下,对所开发的混合纳米粒子进行了抗菌活性测试。结果发现,HNY-AgNPs 对变异链球菌和金黄色葡萄球菌这两种细菌菌株都有活性。HNY-AgNPs-MSN 混合种植体展示了潜在的新型牙科种植体,可为先进牙科种植体的制造提供有效的设计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis and characterization of honey based hybrid dental implants with enhanced antibacterial activity.

Dental implants are commonly used for tooth replacement tools due to their good oral rehabilitation and reconstruction capacities. Dental implants treatment for natural teeth is desired to achieve successful implants treatment with improved osseointegration through promotion of mammalian cell activity and prevention of bacterial activity. Honey is potentially known for its antimicrobial and antibacterial potential, specifically for burns and wound healing. In this study, honey based silver nanoparticles were synthesized using various concentrations of honey. The synthesized HNY-AgNPs, MSN and HNY-AgMSN were characterized for their surface Plasmon resonance using UV spectroscopy, Hydrodynamic diameter using Zetasizer. Morphology using AFM. Furthermore, surface functional groups were characterized using FTIR spectroscopy at 4cm-1 resolutions. The developed hybrid nanoparticles were tested for their anti-bacterial activity at concentration of 3000µg/mL. It was found HNY-AgNPs was active against both bacterial strains i.e, Streptococcus mutans and streptococcus aureus. HNY-AgNPs-MSN hybrid implant demonstrated potential new type of dental implants, which can offer an effective design for the fabrication of advanced dental implants.

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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
211
审稿时长
4.5 months
期刊介绍: Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.
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