使用美托咪定、咪达唑仑和芬太尼联合镇静剂对大鼠服用华蟾素的影响

IF 1.9 2区 农林科学 Q2 VETERINARY SCIENCES
Emily Lindh, Anna Meller, Marja Raekallio
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引用次数: 0

摘要

背景:α2-肾上腺素受体激动剂(α2-激动剂)被广泛用作动物镇静剂和麻醉前用药。美托咪定经常被用于大鼠皮下注射(SC),尽管其吸收速度较慢,而且通过这种途径血清药物浓度的个体差异较大。此外,α2-激动剂对代谢和内分泌功能有各种影响,如低胰岛素血症、高血糖和利尿。华替诺生是一种外周作用的α2-肾上腺素受体拮抗剂,作为一种亲水性分子,它不会大量通过血脑屏障,因此可减轻α2-受体激动剂对外周心血管的影响和对代谢的不良影响。本研究的目的是评估伐替诺生对使用皮下注射美托咪定、咪达唑仑和芬太尼镇静的大鼠的镇静、血糖浓度、排尿、心率和呼吸频率以及动脉血氧饱和度的影响:结果:使用华替诺生后,镇静开始和右反射消失的时间明显更快[分别为 5.35 ± 1.08(平均 ± SD)分钟对 12.97 ± 6.18 分钟和 6.53 ± 2.18 分钟对 14.47 ± 7.28 分钟]。不同治疗方法的心率、呼吸频率和动脉血氧饱和度无明显差异。血糖浓度(18.3 ± 3.6 对 11.8 ± 1.2 mmol/L)和自发性排尿量[35.9(15.1-41.6),范围(中位数)对 0.9(0-8.0) mL /kg/min]在未使用华替诺生的情况下明显更高:结论:在使用皮下注射美托咪定、咪达唑仑和芬太尼诱导临床和实验用大鼠镇静时,使用华替诺生可加速诱导镇静、缓解高血糖和防止大量利尿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of vatinoxan in rats sedated with a combination of medetomidine, midazolam and fentanyl.

Background: Alpha2-adrenoceptor agonists (α2-agonists) are widely used in animals as sedatives and for pre-anaesthetic medication. Medetomidine has often been given subcutaneously (SC) to rats, although its absorption rate is slow and the individual variation in serum drug concentrations is high via this route. In addition, α2-agonists have various effects on metabolic and endocrine functions such as hypoinsulinaemia, hyperglycaemia and diuresis. Vatinoxan is a peripherally acting α2-adrenoceptor antagonist that, as a hydrophilic molecule, does not cross the blood-brain barrier in significant quantities and thus alleviates peripheral cardiovascular effects and adverse metabolic effects of α2-agonists. Aim of this study was to evaluate the effects of vatinoxan on sedation, blood glucose concentration, voiding and heart and respiratory rates and arterial oxygen saturation in rats sedated with subcutaneous medetomidine, midazolam and fentanyl.

Results: Onset of sedation and loss of righting reflex occurred significantly faster with vatinoxan [5.35 ± 1.08 (mean ± SD) versus 12.97 ± 6.18 min and 6.53 ± 2.18 versus 14.47 ± 7.28 min, respectively]. No significant differences were detected in heart and respiratory rates and arterial oxygen saturation between treatments. Blood glucose concentration (18.3 ± 3.6 versus 11.8 ± 1.2 mmol/L) and spontaneous urinary voiding [35.9 (15.1-41.6), range (median) versus 0.9 (0-8.0) mL /kg/min] were significantly higher without vatinoxan.

Conclusions: Acceleration of induction of sedation, alleviation of hyperglycaemia and prevention of profuse diuresis by vatinoxan may be beneficial when sedating rats for clinical and experimental purposes with subcutaneous medetomidine, midazolam and fentanyl.

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来源期刊
Acta Veterinaria Scandinavica
Acta Veterinaria Scandinavica 农林科学-兽医学
CiteScore
3.60
自引率
0.00%
发文量
28
审稿时长
18-36 weeks
期刊介绍: Acta Veterinaria Scandinavica is an open access journal encompassing all aspects of veterinary research and medicine of domestic and wild animals.
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