无机金属纳米粒子在衰老和衰老相关疾病中的生物医学应用。

IF 13 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2025-05-01 DOI:10.1016/j.jare.2024.05.023

Yuqing Meng , Junzhe Zhang , Yanqing Liu , Yongping Zhu , Haining Lv , Fei Xia , Qiuyan Guo , Qianli Shi , Chong Qiu , Jigang Wang

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引用次数: 0

摘要

衰老和衰老相关疾病（AAD），包括神经退行性疾病、癌症、心血管疾病和糖尿病，是一个不可避免的过程。随着生活方式的逐步改善，人们的预期寿命逐渐延长。然而，寿命的延长并没有降低疾病的发病率，大多数老年人在晚年都处于健康不佳的状态。因此，了解衰老和 AAD 对减轻老年人的负担意义重大。无机金属纳米粒子（IMNPs）主要包括金、银、铁、锌、钛、铊、铂、铈、铜等纳米粒子，因其优越的性质（人体必需的金属离子、易合成和修饰、磁性），已被广泛用于预防和治疗衰老和 AAD。因此，系统综述衰老细胞的常见形态变化、衰老和 AAD 中基因和信号通路的改变以及 IMNPs 在衰老和 AAD 中的生物医学应用，对于进一步研究和开发 IMNPs 在衰老和 AAD 中的应用至关重要。本综述重点关注过去十年中有关细胞衰老、老化和 AAD 的现有研究，以及 IMNPs 在老化和 AAD 中的应用。本综述旨在提供有关衰老和 AAD 的前沿知识，以及 IMNPs 在衰老和 AAD 中的应用，以促进 IMNPs 在衰老和 AAD 中的生物医学应用。

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The biomedical application of inorganic metal nanoparticles in aging and aging-associated diseases

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The biomedical application of inorganic metal nanoparticles in aging and aging-associated diseases

Aging and aging-associated diseases (AAD), including neurodegenerative disease, cancer, cardiovascular diseases, and diabetes, are inevitable process. With the gradual improvement of life style, life expectancy is gradually extended. However, the extended lifespan has not reduced the incidence of disease, and most elderly people are in ill-health state in their later years. Hence, understanding aging and AAD are significant for reducing the burden of the elderly. Inorganic metal nanoparticles (IMNPs) predominantly include gold, silver, iron, zinc, titanium, thallium, platinum, cerium, copper NPs, which has been widely used to prevent and treat aging and AAD due to their superior properties (essential metal ions for human body, easily synthesis and modification, magnetism). Therefore, a systematic review of common morphological alternations of senescent cells, altered genes and signal pathways in aging and AAD, and biomedical applications of IMNPs in aging and AAD is crucial for the further research and development of IMNPs in aging and AAD. This review focus on the existing research on cellular senescence, aging and AAD, as well as the applications of IMNPs in aging and AAD in the past decade. This review aims to provide cutting-edge knowledge involved with aging and AAD, the application of IMNPs in aging and AAD to promote the biomedical application of IMNPs in aging and AAD.

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.