免疫介导的慢性炎症患者肱动脉血压和主动脉血压的短期变异性都会增加。

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE
Panagiota Anyfanti, Areti Triantafyllou, Antonios Lazaridis, Anastasia Malliora, Anastasia Margouta, Agapi Chionidou, Barbara Nikolaidou, Vasileios Kotsis, Eugenia Gkaliagkousi
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引用次数: 0

摘要

简介:目的:我们旨在评估银屑病患者肱动脉和主动脉血压的短期变化,银屑病是一种常见的免疫介导的炎症性疾病,其特征是心血管疾病风险增加:方法:银屑病患者和非银屑病患者在 24 小时内接受血压评估(Mobil-O-Graph 设备)。根据相关的非卧床血压曲线计算出 24 小时内的肱动脉和主动脉血压值,以及各自的白天和夜间血压值。应用内部软件自动计算肱动脉和主动脉收缩压(bSBP、aSBP)和舒张压(bDPB、aDBP)的平均实际变异性(ARV),以及 24 小时 bSBP/aSBP 的加权标准偏差(wSD)。24 h脉搏波速度(PWV)和增强指数(AIx)是广泛应用的动脉僵化指标:结果:与对照组(n = 40)相比,银屑病患者(n = 74)的 24 小时 ARV 和日间 bSBP/aSBP 增加,24 小时 ARV 和日间 bDBP/aDBP 增加。脉搏波速度和人工指数与 24 小时 bSBP/aSBP 和白天 bSBP/aSBP 的 ARV 相关,而脉搏波速度与夜间 aSBP 的 ARV 进一步相关。在对心血管疾病风险因素进行调整后,观察到的脉搏波速度(而非脉搏指数)与血压升高指数的关系仍然显著:这是首个报告银屑病患者肱动脉和主动脉血压 24 小时变异性增加的研究。短期血压变异性与动脉僵化的关联意味着,血压变异性在慢性免疫介导炎症患者的心血管疾病风险分层方面具有潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short-Term Variability of Both Brachial and Aortic Blood Pressure is Increased in Patients with Immune-mediated Chronic Inflammation.

Introduction: Blood pressure (BP) variability (BPV) has emerged as an indicator of subclinical organ damage and an independent predictor of cardiovascular disease (CVD) morbidity and mortality in high-risk populations.

Aim: We aimed to assess short-term variability of both brachial and aortic BP in psoriasis, a common immune-mediated inflammatory disorder characterized by increased CVD risk.

Methods: Psoriasis patients and non-psoriasis individuals had their BP assessed throughout a 24 h period (Mobil-O-Graph device). Brachial and aortic BPV during the 24 h and the respective daytime and nighttime periods was calculated from relevant ambulatory BP profiles. In-house software was applied to automatically calculate average real variability (ARV) of brachial and aortic systolic (bSBP, aSBP) and diastolic BP (bDPB, aDBP), and the weighted standard deviation (wSD) of 24 h bSBP/aSBP. 24 h pulse wave velocity (PWV) and augmentation index (AIx) were used as widely applied markers of arterial stiffness.

Results: Psoriasis patients (n = 74) presented increased ARV of 24 h and daytime bSBP/aSBP, and increased ARV of 24 h and daytime bDBP/aDBP, compared to controls (n = 40). PWV and AIx correlated with ARV of 24 h bSBP/aSBP, daytime bSBP/aSBP, while PWV further correlated with ARV of nighttime aSBP. The observed associations with PWV, yet not AIx, with indices of BPV remained significant after adjusting for CVD risk factors.

Conclusions: This is the first study reporting increased 24 h variability of both brachial and aortic BP in psoriasis. The association of short-term BPV with arterial stiffness implies a potential role of BPV in terms of CVD risk stratification in patients with chronic immune-mediated inflammation.

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来源期刊
CiteScore
5.70
自引率
3.30%
发文量
57
期刊介绍: High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes:   Invited ''State of the Art'' reviews.  Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.
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