一名乙型肝炎疫苗非应答者患急性乙型肝炎。

IF 1.4 4区医学 Q4 IMMUNOLOGY

International Journal of STD & AIDS Pub Date : 2024-09-01 Epub Date: 2024-05-31 DOI:10.1177/09564624241258277

Kanch Seneviratne, Jane Scott, Soumeya Cherif

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引用次数: 0

摘要

免疫功能正常但对乙型肝炎疫苗接种无反应者患急性乙型肝炎的报道很少。我们报告了这样一个病例，患者是一名 79 岁的异性恋男性。有证据表明，替诺福韦酯/恩曲他滨作为主要预防药物可以预防乙型肝炎的感染。在当前使用替诺福韦酯/恩曲他滨进行艾滋病暴露前预防 (PrEP) 的时代，预防艾滋病和乙型肝炎具有双重益处。我们讨论了在乙肝疫苗接种未应答者中考虑使用替诺福韦酯/恩曲他滨进行暴露前预防的重要性。

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Acute hepatitis B in a hepatitis B vaccine non-responder.

Developing acute hepatitis B in immunocompetent non-responders to hepatitis B vaccination has been rarely reported. We report such a case in a 79 year old heterosexual male. There is evidence that tenofovir disoproxil/emtricitabine as primary prophylaxis can prevent acquisition of hepatitis B. In the current era of HIV pre-exposure prophylaxis (PrEP) with tenofovir disoproxil/emtricitabine, there is dual benefit of preventing HIV and hepatitis B. We discuss the importance of considering tenofovir disoproxil/emtricitabine pre-exposure prophylaxis in those hepatitis B vaccination non-responders at high risk of acquiring hepatitis B.

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来源期刊

International Journal of STD & AIDS 医学-传染病学

CiteScore

2.60

自引率

7.10%

发文量

144

审稿时长

3-6 weeks

期刊介绍： The International Journal of STD & AIDS provides a clinically oriented forum for investigating and treating sexually transmissible infections, HIV and AIDS. Publishing original research and practical papers, the journal contains in-depth review articles, short papers, case reports, audit reports, CPD papers and a lively correspondence column. This journal is a member of the Committee on Publication Ethics (COPE).