洞察牙周袋内发病机制、治疗、体外体内模型、产品和专利、挑战和机遇。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Sumel Ashique, Afzal Hussain, Tasneem Khan, Sejuti Pal, Mohd. Rihan, Arshad Farid, Thomas J. Webster, Mohd. Zaheen Hassan, Yahya I. Asiri
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引用次数: 0

摘要

牙周病是一种多因素致病条件,涉及微生物感染、炎症和各种全身并发症。本文通过系统全面的综述,讨论了传统方法的利弊、新进展、挑战、专利和产品以及未来前景等关键点。本文采用了系统性综述流程,使用了以下关键词:牙周疾病、发病机制、模型、专利、挑战、最新发展和 3-D 打印支架。使用的搜索引擎包括 "google scholar"、"web of science"、"scopus "和 "pubmed",以及过去几十年出版的教科书。通过对已发表数据的深入研究,我们对牙周疾病、迄今为止的研究差距以及未来的机遇有了准确而深刻的认识。制剂科学家和医生需要相互联系,以便更好地了解疾病,从而开出高质量的产品。此外,要设计出优质的新产品,还必须应对一些主要挑战(如缺乏重要的测试模型、临床和临床前数据稀缺、产品允许药物进入深层组织区域并长时间停留、缺乏国际监测机构、缺乏 4D 或时间控制支架,以及缺乏成功的人工智能工具)。一般来说,一些治疗牙周疾病的产品已经商业化,但存在一定的局限性。人们尝试了各种战略方法,以针对某些输送区域、最大限度地延长停留时间、提高疗效并降低毒性。总之,本综述为研究人员和医疗保健专业人员治疗各种牙周疾病总结了宝贵的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Insights into Intra Periodontal Pocket Pathogenesis, Treatment, In Vitro-In Vivo Models, Products and Patents, Challenges and Opportunity

Insights into Intra Periodontal Pocket Pathogenesis, Treatment, In Vitro-In Vivo Models, Products and Patents, Challenges and Opportunity

Periodontal disease is a multifactorial pathogenic condition involving microbial infection, inflammation, and various systemic complications. Here, a systematic and comprehensive review discussing key-points such as the pros and cons of conventional methods, new advancements, challenges, patents and products, and future prospects is presented. A systematic review process was adopted here by using the following keywords: periodontal diseases, pathogenesis, models, patents, challenges, recent developments, and 3-D printing scaffolds. Search engines used were “google scholar”, “web of science”, “scopus”, and “pubmed”, along with textbooks published over the last few decades. A thorough study of the published data rendered an accurate and deep understanding of periodontal diseases, the gap of research so far, and future opportunities. Formulation scientists and doctors need to be interconnected for a better understanding of the disease to prescribe a quality product. Moreover, prime challenges (such as a lack of a vital testing model, scarcity of clinical and preclinical data, products allowing for high drug access to deeper tissue regions for prolonged residence, lack of an international monitoring body, lack of 4D or time controlled scaffolds, and lack of successful AI based tools) exist that must be addressed for designing new quality products. Generally, several products have been commercialized to treat periodontal diseases with certain limitations. Various strategic approaches have been attempted to target certain delivery regions, maximize residence time, improve efficacy, and reduce toxicity. Conclusively, the current review summarizes valuable information for researchers and healthcare professional to treat a wide range of periodontal diseases.

Graphical Abstract

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CiteScore
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