Gabriele Giovanardi, Silvia Cattani, Davide Balestri, Andrea Secchi and Gianpiero Cera*,
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Iridium-Catalyzed C–H Borylations: Regioselective Functionalizations of Calix[4]arene Macrocycles
We report iridium-catalyzed C–H borylations for the regioselective synthesis of distally disubstituted calix[4]arene macrocycles. The atom- and step-economical method led to a broad family of calix[4]arenes in good yields and functional group tolerance. The synthetic utility of the C–H borylation protocol was finally illustrated with several late-stage modifications for the synthesis of elaborate calix[4]arenes frameworks, otherwise challenging to achieve with commonly employed procedures.
期刊介绍:
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.