铱催化的 C-H 硼酰化反应:钙[4]炔大环的区域选择性官能化。

IF 3.6 2区 化学 Q1 CHEMISTRY, ORGANIC
Gabriele Giovanardi, Silvia Cattani, Davide Balestri, Andrea Secchi and Gianpiero Cera*, 
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引用次数: 0

摘要

我们报告了铱催化 C-H 硼烷基化区域选择性合成远端二取代的钙[4]炔大环。这种原子和步长经济的方法产生了一系列具有良好产率和官能团耐受性的钙[4]炔化合物。C-H 玻里化协议的合成实用性最终通过几个后期修改得以体现,这些修改用于合成精细的钙[4]炔框架,否则常用的程序难以实现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Iridium-Catalyzed C–H Borylations: Regioselective Functionalizations of Calix[4]arene Macrocycles

Iridium-Catalyzed C–H Borylations: Regioselective Functionalizations of Calix[4]arene Macrocycles

Iridium-Catalyzed C–H Borylations: Regioselective Functionalizations of Calix[4]arene Macrocycles

We report iridium-catalyzed C–H borylations for the regioselective synthesis of distally disubstituted calix[4]arene macrocycles. The atom- and step-economical method led to a broad family of calix[4]arenes in good yields and functional group tolerance. The synthetic utility of the C–H borylation protocol was finally illustrated with several late-stage modifications for the synthesis of elaborate calix[4]arenes frameworks, otherwise challenging to achieve with commonly employed procedures.

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来源期刊
Journal of Organic Chemistry
Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍: Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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