嵌入闭环心血管模拟器的患者特异性回声软机器人左心室,用于先进设备测试。

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL
APL Bioengineering Pub Date : 2024-05-28 eCollection Date: 2024-06-01 DOI:10.1063/5.0203653
Maria Rocchi, Konstantina Papangelopoulou, Marcus Ingram, Youri Bekhuis, Guido Claessen, Piet Claus, Jan D'hooge, Dirk W Donker, Bart Meyns, Libera Fresiello
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引用次数: 0

摘要

心血管医疗设备在获准用于临床之前,需要经过大量的上市前和上市后测试。先进的心血管模拟器可提供安全、受控的环境,并表现与临床相关的病例场景,从而大大加快评估过程。受严重病症影响的心血管系统性质复杂,病人与设备之间的互动错综复杂,因此需要能够再现病人内部和病人之间疾病状态变化的高保真测试台。因此,我们提出了一种创新的心血管模拟器,它将硅学和体外建模技术与软机器人左心室相结合。该模拟器利用患者特异性和回声性的软机器人模型来再现心内压力和容积波形,并结合其余心血管系统的硅学集合参数模型。该模拟器重现了三种不同的病人特征,以评估模拟器表现各种工作条件和左心室机械特性的能力。该模拟器采用软机器人技术,并结合硅建模,能够真实再现生理和解剖结构。事实证明,该工具对于优化和验证医疗设备以及划定特定适应症和边界条件非常有价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A patient-specific echogenic soft robotic left ventricle embedded into a closed-loop cardiovascular simulator for advanced device testing.

Cardiovascular medical devices undergo a large number of pre- and post-market tests before their approval for clinical practice use. Sophisticated cardiovascular simulators can significantly expedite the evaluation process by providing a safe and controlled environment and representing clinically relevant case scenarios. The complex nature of the cardiovascular system affected by severe pathologies and the inherently intricate patient-device interaction creates a need for high-fidelity test benches able to reproduce intra- and inter-patient variability of disease states. Therefore, we propose an innovative cardiovascular simulator that combines in silico and in vitro modeling techniques with a soft robotic left ventricle. The simulator leverages patient-specific and echogenic soft robotic phantoms used to recreate the intracardiac pressure and volume waveforms, combined with an in silico lumped parameter model of the remaining cardiovascular system. Three different patient-specific profiles were recreated, to assess the capability of the simulator to represent a variety of working conditions and mechanical properties of the left ventricle. The simulator is shown to provide a realistic physiological and anatomical representation thanks to the use of soft robotics combined with in silico modeling. This tool proves valuable for optimizing and validating medical devices and delineating specific indications and boundary conditions.

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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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