移植骨髓对辐照怀孕大鼠及其胎儿脾脏的影响

Q3 Agricultural and Biological Sciences
Mervat Ahmed Abd Rabou, Ali Hassan A Ali, Kamal R El Baz, Mohammed Saad Alqahtani, Aljohara M Al-Otaibi, Haifa E Alfassam, Heba F Ibrahim, Amany M Abo-Ouf, Heba Abdelnaser Aboelsoud, Mehad A Ahmed, Sahar Gamil, Ibrahim M Ibrahim Alturaiki, Mohammed Mudhhi Awadh Alanazi
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引用次数: 0

摘要

<b>背景和目的:</b> 产前电离辐射照射可能会阻碍胎儿和胚胎的生长,这取决于剂量和胎龄。本研究的目的是了解骨髓移植对接受过 γ(伽马)辐射的怀孕大鼠的脾脏有何影响。 <b>材料与方法:</b> 60 只怀孕大鼠被分成 5 组,每组 6 只雌鼠。第一组;妊娠大鼠接受 2Gy γ 射线照射;第二组;妊娠大鼠接受 2Gy γ 射线照射;第三组;妊娠大鼠接受 2Gy γ 射线照射。第三组;怀孕大鼠接受 2Gy γ 射线照射,然后腹腔注射新制备的骨髓移植(BMT)。第五组接受 2Gy γ 射线照射,一小时后接受 1 剂骨髓移植。结果:</b> γ射线对妊娠第 7 天或第 14 天的母鼠及其胎儿的脾脏组织造成了不同程度的组织学和组织化学损伤,但骨髓移植明显减轻了这种损伤。接受放射后骨髓治疗的母亲,其胎儿的脾脏明显恢复。特别是在妊娠第 7 天,胎儿脾脏组织中的胶原蛋白、多糖和总蛋白含量正常,脾脏结构得到改善。 <b>结论:</b> 骨髓移植可减轻伽马射线造成的损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Transplanted Bone Marrow on Spleen of Irradiated Pregnant Rats and Their Fetuses.

<b>Background and Objective:</b> Prenatal ionizing radiation exposure may hinder fetal and embryonic growth depending on the dose and gestational age. The current study's objective was to discover how bone marrow transplants affected the spleens of pregnant rats that had been subjected to γ (Gamma) radiation. <b>Materials and Methods:</b> Sixty rats that were pregnant were separated into five different groups, each with 6 females. The pregnant rats in the second Group were exposed to 2Gy of γ-rays. Group III; pregnant rats subjected to 2Gy of γ-rays, followed by an intraperitoneal injection of newly prepared bone marrow transplantation (BMT). The fifth Group were exposed to 2Gy γ-rays and received 1 dosage of BMT an hour later. Spleen samples from the pregnant rats as well as their fetuses were taken for histological and histochemical analyses. <b>Results:</b> Gamma rays damaged the splenic tissue of women and their fetuses on days 7 or 14 of pregnancy in a variety of histological and histochemical ways, although bone marrow transplantation significantly reduced the damage. Treated mothers with bone marrow post-radiation showed a noticeable recovery in spleen of their fetuses. Improved spleen architecture was accompanied by appearance of normal content of collagen, polysaccharides and total protein in the fetal spleen tissue especially on day 7 of gestation. <b>Conclusion:</b> Bone marrow transplantation can lessen the damage caused by gamma radiation.

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来源期刊
Pakistan Journal of Biological Sciences
Pakistan Journal of Biological Sciences Agricultural and Biological Sciences-Agronomy and Crop Science
CiteScore
1.90
自引率
0.00%
发文量
102
期刊介绍: Pakistan Journal of Biological Sciences (PJBS) is an international, peer-reviewed and well indexed scientific journal seeks to promote and disseminate the knowledge of biological sciences by publishing outstanding research in the field. Scope of the journal includes: Cell biology, developmental biology, structural biology, microbiology, entomology, toxicology, molecular biology & genetics, biochemistry, biotechnology, biodiversity, ecology, marine biology, plant biology and bioinformatics.
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