Julia Rius-Bonet, Salvador Macip, Daniel Closa, Marta Massip-Salcedo
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引用次数: 0
摘要
事实证明,间歇性禁食(IF)对更多人群来说是一种可行的饮食干预措施。最近,间歇性禁食临床试验的增加突显了其对健康的潜在影响,包括身体成分、心脏代谢状况和衰老的变化。尽管 IF 可应用于不同人群的临床,但研究表明,在身体成分或葡萄糖和脂质代谢等参数方面可能存在性别特异性反应。在此,我们总结了现有的 IF 临床试验文献,讨论了 IF 在疾病预防和管理中的应用,并评估了男性和女性对这类饮食的潜在反应差异。此外,还研究了可能导致性别双态反应的潜在机制,如年龄、身体成分、组织分布或性激素。这篇综述强调了进一步研究 IF 性别特异性反应的必要性,以确定男性和女性最有效的禁食时间框架和禁食期长度。以个性化的方法为特定人群量身定制 IF,可能有助于充分发挥其作为一种生活方式干预措施的潜力,并带来临床益处。
Intermittent fasting as a dietary intervention with potential sexually dimorphic health benefits.
Intermittent fasting (IF) has proven to be a feasible dietary intervention for the wider population. The recent increase in IF clinical trials highlights its potential effects on health, including changes in body composition, cardiometabolic status, and aging. Although IF may have clinical applications in different populations, studies suggest there may be sex-specific responses in parameters such as body composition or glucose and lipid metabolism. Here, the existing literature on IF clinical trials is summarized, the application of IF in both disease prevention and management is discussed, and potential disparities in response to this type of diet between men and women are assessed. Moreover, the potential mechanisms that may be contributing to the sexually dimorphic response, such as age, body composition, tissue distribution, or sex hormones are investigated. This review underscores the need to further study these sex-specific responses to IF to define the most effective time frames and length of fasting periods for men and women. Tailoring IF to specific populations with a personalized approach may help achieve its full potential as a lifestyle intervention with clinical benefits.
期刊介绍:
Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.