重型血小板增多症患者大脑中动脉原位血栓导致的反复缺血性中风。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-01-15 Epub Date: 2024-05-30 DOI:10.2169/internalmedicine.3590-24

Toru Nakagami, Yuji Kato, Kaito Watanabe, Ryutaro Kimura, Tsugumi Sato, Takeshi Hayashi, Satoshi Suda

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引用次数: 0

摘要

原发性血小板增多症（ET）是一种骨髓增生性肿瘤，是缺血性中风的罕见病因。我们在此报告了一名患有 JAK2 V617F 突变阳性 ET 的 70 岁男性患者，他在一个月内因一过性血管狭窄导致两次缺血性中风。在这两次事件中，一过性狭窄均在右侧大脑中动脉的同一弯曲处形成，血栓在使用抗血小板药物后消失。在颅内血管弯曲处形成原位血栓可能是JAK2 V617F突变阳性ET患者的一个独特特征。

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Repeated Ischemic Stroke due to in situ Thrombus at the Middle Cerebral Artery in a Patient with Essential Thrombocythemia.

Essential thrombocythemia (ET) is a myeloproliferative neoplasm that is a rare cause of ischemic stroke. We herein report a 70-year-old man with JAK2 V617F mutation-positive ET who experienced ischemic stroke twice in 1 month due to transient stenosis. In both events, transient stenosis formed at the same curvature of the right middle cerebral artery, and the thrombus disappeared with the initiation of antiplatelet agents. The formation of in situ thrombus at the curvature of the intracranial vessels may be a unique characteristic of JAK2 V617F mutation-positive ET patients.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.