自身免疫性疾病与口咽癌之间是否存在因果关系？

IF 0.9 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Community dental health Pub Date : 2024-05-31 DOI:10.1922/CDH_00274Hua07

S Hua, T Lang, R Liu, D Hou

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引用次数: 0

摘要

背景：自身免疫性疾病（AID）与口咽癌（OPC）有关，但这种关联的确切性质仍不清楚。本研究旨在探讨自身免疫性疾病对口咽癌发病风险的潜在因果关系：有关艾滋病的信息来自英国生物库数据集和芬兰基因研究。OPC数据来自IEU Open GWAS项目。所有数据均来自欧洲人群。通过加权中位数和 MR Egger 验证分析对反方差加权（IVW）和双样本孟德尔随机化（MR）进行了补充：结果：哮喘（AS）、多发性硬化症（MS）和类风湿性关节炎（RA）的发病会影响 OPC 的发病风险。然而，反向磁共振分析并未提供证据证明 OPC 对艾滋病的影响。使用 MR 进行的敏感性分析证实了 IVW 的结果。IVW 结果显示，强直性脊柱炎的 OR 值为 1.004，多发性硬化症的 OR 值为 0.936，而 RA 的 OR 值为 1.0002：这项磁共振研究证实，在欧洲人群中，哮喘和类风湿性关节炎与 OPC 之间存在因果关系。多发性硬化症对 OPC 具有保护作用。

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Is there a causal relationship between autoimmune diseases and oropharyngeal cancer?

Background: Autoimmune diseases (AIDs) are linked to oropharyngeal cancer (OPC), but the exact nature of this association remains unclear. This study aims to examine the potential causal effect of AIDs on the risk of developing OPC.

Method: Information regarding AIDs was collected from the UK Biobank dataset and the Finn Gen study. OPC data were sourced from the IEU Open GWAS project. All data were derived from European populations. Inverse variance weighted (IVW) to two-sample Mendelian randomization (MR) was complemented by weighted median and MR Egger validation analyses.

Result: The development of asthma (AS), multiple sclerosis (MS), and rheumatoid arthritis (RA) influenced the risk of developing OPC. However, the reverse MR analysis did not provide evidence for the impact of OPC on AIDs. Sensitivity analysis using MR corroborated the IVW results. The IVW results indicate OR values of 1.004 for AS, 0.936 for MS, and 1.0002 for RA.

Conclusion: This MR study supports a causal relationship between asthma and rheumatoid arthritis for OPC in a European population. Multiple sclerosis was protective against OPC.

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来源期刊

Community dental health 医学-牙科与口腔外科

CiteScore

2.20

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is concerned with dental public health and related subjects. Dental public health is the science and the art of preventing oral disease, promoting oral health, and improving the quality of life through the organised efforts of society. The discipline covers a wide range and includes such topics as: -oral epidemiology- oral health services research- preventive dentistry - especially in relation to communities- oral health education and promotion- clinical research - with particular emphasis on the care of special groups- behavioural sciences related to dentistry- decision theory- quality of life- risk analysis- ethics and oral health economics- quality assessment. The journal publishes scientific articles on the relevant fields, review articles, discussion papers, news items, and editorials. It is of interest to dentists working in dental public health and to other professionals concerned with disease prevention, health service planning, and health promotion throughout the world. In the case of epidemiology of oral diseases the Journal prioritises national studies unless local studies have major methodological innovations or information of particular interest.