结肠给药系统的最新方法概览。

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Pharmaceutical Development and Technology Pub Date : 2024-07-01 Epub Date: 2024-06-20 DOI:10.1080/10837450.2024.2362353

Aylin Deljavan Ghodrati, Tansel Comoglu

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引用次数: 0

摘要

结肠靶向给药系统作为一种潜在的解决方案引起了人们的极大兴趣，它可以给各种容易在胃肠道（GI）中被酸性和催化降解的药物提供给药，也可以作为一种自然治疗结肠疾病且总体副作用较小的手段。对方便患者用药的需求日益增长，这凸显了结肠给药的重要性，尤其是通过纳米颗粒给药技术等非侵入性方法。此类系统可提高患者的依从性，降低成本，并具有治疗优势。本研究特别强调制剂，并讨论了设计结肠靶向给药系统及其药物应用的各种方法的最新进展。

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An overview on recent approaches for colonic drug delivery systems.

Colon-targeted drug delivery systems have garnered significant interest as potential solutions for delivering various medications susceptible to acidic and catalytic degradation in the gastrointestinal (GI) tract or as a means of treating colonic diseases naturally with fewer overall side effects. The increasing demand for patient-friendly drug administration underscores the importance of colonic drug delivery, particularly through noninvasive methods like nanoparticulate drug delivery technologies. Such systems offer improved patient compliance, cost reduction, and therapeutic advantages. This study places particular emphasis on formulations and discusses recent advancements in various methods for designing colon-targeted drug delivery systems and their medicinal applications.

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来源期刊

Pharmaceutical Development and Technology 医学-药学

CiteScore

5.90

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Pharmaceutical Development & Technology publishes research on the design, development, manufacture, and evaluation of conventional and novel drug delivery systems, emphasizing practical solutions and applications to theoretical and research-based problems. The journal aims to publish significant, innovative and original research to advance the frontiers of pharmaceutical development and technology. Through original articles, reviews (where prior discussion with the EIC is encouraged), short reports, book reviews and technical notes, Pharmaceutical Development & Technology covers aspects such as: -Preformulation and pharmaceutical formulation studies -Pharmaceutical materials selection and characterization -Pharmaceutical process development, engineering, scale-up and industrialisation, and process validation -QbD in the form a risk assessment and DoE driven approaches -Design of dosage forms and drug delivery systems -Emerging pharmaceutical formulation and drug delivery technologies with a focus on personalised therapies -Drug delivery systems research and quality improvement -Pharmaceutical regulatory affairs This journal will not consider for publication manuscripts focusing purely on clinical evaluations, botanicals, or animal models.