提高人类健康水平和寿命:强调他汀类药物的针对性战略。

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Biogerontology Pub Date : 2024-10-01 Epub Date: 2024-05-29 DOI:10.1007/s10522-024-10112-y
Edward Calabrese, Peter Pressman
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引用次数: 0

摘要

人们对寻找能够延缓多种老年疾病/病症的发生和减轻其严重程度的活动/制剂有着浓厚的研究兴趣。这项评估表明,在针对多种疾病的人类人群调查中,研究最多的旨在促进健康的药物是他汀类药物,其大规模流行病学研究涉及众多健康终点。主要研究结果表明,他汀类药物治疗可持续降低多种非传染性和传染性疾病以及多种高死亡率癌症的发病率,并使其病程缩短约 20%-50%。在流行病学研究中,一种药物能够影响如此广泛且持续的积极趋势,这一点出乎意料,令人印象深刻,而且细胞和动物模型研究也是如此。他汀类药物的生物利用度和广泛的组织分布,特别是其激活 Nrf2 的能力,在多个器官和细胞类型中显示出激素剂量反应,是他汀类药物产生一系列有益影响的重要原因。他汀类药物具有增进人类健康的能力,因此应考虑将其广泛使用作为一项新的公共卫生战略进行实验探索,其中包括减少这类药物最常见不良反应(包括肌痛/肌病和转氨酶炎)的实用方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhancing the human health and lifespan: a targeted strategy emphasizing statins.

There has been substantial research interest in finding activities/agents that slow the onset and reduce the severity of numerous age-related diseases/conditions. This assessment indicates that the most studied agent intended to promote health in human population investigations for a broad spectrum of diseases are the statins, with large-scale epidemiological studies addressing numerous health endpoints. The key findings are that statin treatment consistently reduces the occurrence and attenuates the course of numerous non-communicable and contagious pathologies and numerous types of cancer with high mortality rates by about 20-50%. That one agent could affect such a broad based and consistently positive trends in epidemiological studies is unexpected and impressive, along with consistent cell and animal model research. Underlying mechanisms have been proposed that significantly contribute to the spectrum of salutary effects of statins, especially the capacity to activate Nrf2 showing hormetic dose responses in multiple organs and cell types, due to its bioavailability and broad tissue distribution. The widespread use of statins, which has the capacity to enhance human health span, should be considered for experimental exploration as a novel public health strategy that includes practical approaches for reduction of the most common adverse effects of this class of drugs including myalgia/myopathy and transaminitis.

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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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