人体细胞中的高亲和性色氨酸吸收转运系统。

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Society transactions Pub Date : 2024-06-26 DOI:10.1042/BST20230742

Keisuke Wakasugi, Takumi Yokosawa

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引用次数: 0

摘要

L-色氨酸（Trp）转运系统对 Trp 具有高度选择性，亲和力在纳摩尔范围内。在经干扰素（IFN）-γ 处理和表达吲哚胺-2,3-二氧化酶 1（IDO1）的细胞中，这种转运系统会增强。细胞对 Trp 吸收的上调会导致细胞外 Trp 的减少，并引发免疫抑制。最近的研究表明，IDO1 和色氨酸-tRNA 合成酶（TrpRS）的表达水平受 IFN-γ 上调，它们在人类细胞吸收高亲和性 Trp 的过程中起着关键作用。此外，色氨酸 2,3-二氧合酶（TDO2）的过表达对 TrpRS 介导的高亲和性 Trp 摄取也有类似于 IDO1 的作用。在这篇综述中，我们总结了有关这一 Trp 摄取系统的最新发现，并提出了一种可能的分子机制，该机制基于 IDO1 或 TDO2 诱导的 Trp 缺乏以及 TrpRS 产生的色氨酸-AMP。

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The high-affinity tryptophan uptake transport system in human cells.

The L-tryptophan (Trp) transport system is highly selective for Trp with affinity in the nanomolar range. This transport system is augmented in human interferon (IFN)-γ-treated and indoleamine 2,3-dioxygenase 1 (IDO1)-expressing cells. Up-regulated cellular uptake of Trp causes a reduction in extracellular Trp and initiates immune suppression. Recent studies demonstrate that both IDO1 and tryptophanyl-tRNA synthetase (TrpRS), whose expression levels are up-regulated by IFN-γ, play a pivotal role in high-affinity Trp uptake into human cells. Furthermore, overexpression of tryptophan 2,3-dioxygenase (TDO2) elicits a similar effect as IDO1 on TrpRS-mediated high-affinity Trp uptake. In this review, we summarize recent findings regarding this Trp uptake system and put forward a possible molecular mechanism based on Trp deficiency induced by IDO1 or TDO2 and tryptophanyl-AMP production by TrpRS.

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来源期刊

Biochemical Society transactions 生物-生化与分子生物学

CiteScore

7.80

自引率

0.00%

发文量

351

审稿时长

3-6 weeks

期刊介绍： Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.