Aslı Yaman Kula, Ahmet Volkan Kurtoğlu, Vildan Güzel, Serdar Balsak, Ayşegül Yabacı Tak, Talip Asil
{"title":"炎症生物标志物与脑静脉窦血栓形成的血栓负荷相关。","authors":"Aslı Yaman Kula, Ahmet Volkan Kurtoğlu, Vildan Güzel, Serdar Balsak, Ayşegül Yabacı Tak, Talip Asil","doi":"10.1055/s-0044-1787137","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong> Increasing evidence suggests that inflammatory biomarkers play a significant role in cerebral venous sinus thrombosis (CVST). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are related to thrombotic conditions and indicators of systemic inflammation.</p><p><strong>Objective: </strong> To analyze the correlation between inflammatory biomarkers and the extent of thrombus, determined by the CVST-Score.</p><p><strong>Methods: </strong> A total of 40 patients with CVST (24 female subjects; 60%) and 40 age- and sex-matched healthy controls were retrospectively evaluated. Inflammatory biomarkers, including C-reactive protein (CRP), PLR, NLR, MLR, and the CVST-Score, were recorded to assess the relationship between biomarkers and thrombus burden. The patients were grouped according to symptom duration (group 1: 0-3 days; group 2: 4-7 days; and group 3: 8-30 days) to compare biomarker levels.</p><p><strong>Results: </strong> The CRP, NLR, and PLR were significantly higher in the CVST group (<i>p</i> < 0.001; <i>p</i> = 0.003; <i>p</i> = 0.014 respectively). The NLR and PLR presented a significant positive correlation with the CVST-Score (<i>p</i> = 0.003, r = 0.464; <i>p</i> = 0.040, r = 0.326 respectively). The NLR was significantly higher in group 1 compared with groups 2 and 3 (<i>p</i> = 0.016 and <i>p</i> = 0.014 respectively). In group 1, there was a stronger positive correlation between the CVST-Score and the NLR (<i>p</i> = 0.026, r = 0.591) and the PLR (<i>p</i> = 0.012, r = 0.648). The multiple linear regression analysis revealed that the NLR is a key factor in predicting the CVST-Score (<i>p</i> = 0.019).</p><p><strong>Conclusion: </strong> The NLR and PLR are associated with thrombus burden in CVST, especially in patients admitted to the hospital in the early stages. The NLR is an independent factor to predict the thrombus burden in CVST.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 5","pages":"1-8"},"PeriodicalIF":1.0000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inflammatory biomarkers are correlated with thrombus burden in cerebral venous sinus thrombosis.\",\"authors\":\"Aslı Yaman Kula, Ahmet Volkan Kurtoğlu, Vildan Güzel, Serdar Balsak, Ayşegül Yabacı Tak, Talip Asil\",\"doi\":\"10.1055/s-0044-1787137\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong> Increasing evidence suggests that inflammatory biomarkers play a significant role in cerebral venous sinus thrombosis (CVST). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are related to thrombotic conditions and indicators of systemic inflammation.</p><p><strong>Objective: </strong> To analyze the correlation between inflammatory biomarkers and the extent of thrombus, determined by the CVST-Score.</p><p><strong>Methods: </strong> A total of 40 patients with CVST (24 female subjects; 60%) and 40 age- and sex-matched healthy controls were retrospectively evaluated. Inflammatory biomarkers, including C-reactive protein (CRP), PLR, NLR, MLR, and the CVST-Score, were recorded to assess the relationship between biomarkers and thrombus burden. The patients were grouped according to symptom duration (group 1: 0-3 days; group 2: 4-7 days; and group 3: 8-30 days) to compare biomarker levels.</p><p><strong>Results: </strong> The CRP, NLR, and PLR were significantly higher in the CVST group (<i>p</i> < 0.001; <i>p</i> = 0.003; <i>p</i> = 0.014 respectively). The NLR and PLR presented a significant positive correlation with the CVST-Score (<i>p</i> = 0.003, r = 0.464; <i>p</i> = 0.040, r = 0.326 respectively). The NLR was significantly higher in group 1 compared with groups 2 and 3 (<i>p</i> = 0.016 and <i>p</i> = 0.014 respectively). In group 1, there was a stronger positive correlation between the CVST-Score and the NLR (<i>p</i> = 0.026, r = 0.591) and the PLR (<i>p</i> = 0.012, r = 0.648). The multiple linear regression analysis revealed that the NLR is a key factor in predicting the CVST-Score (<i>p</i> = 0.019).</p><p><strong>Conclusion: </strong> The NLR and PLR are associated with thrombus burden in CVST, especially in patients admitted to the hospital in the early stages. The NLR is an independent factor to predict the thrombus burden in CVST.</p>\",\"PeriodicalId\":8694,\"journal\":{\"name\":\"Arquivos de neuro-psiquiatria\",\"volume\":\"82 5\",\"pages\":\"1-8\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arquivos de neuro-psiquiatria\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0044-1787137\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arquivos de neuro-psiquiatria","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/s-0044-1787137","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Inflammatory biomarkers are correlated with thrombus burden in cerebral venous sinus thrombosis.
Background: Increasing evidence suggests that inflammatory biomarkers play a significant role in cerebral venous sinus thrombosis (CVST). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are related to thrombotic conditions and indicators of systemic inflammation.
Objective: To analyze the correlation between inflammatory biomarkers and the extent of thrombus, determined by the CVST-Score.
Methods: A total of 40 patients with CVST (24 female subjects; 60%) and 40 age- and sex-matched healthy controls were retrospectively evaluated. Inflammatory biomarkers, including C-reactive protein (CRP), PLR, NLR, MLR, and the CVST-Score, were recorded to assess the relationship between biomarkers and thrombus burden. The patients were grouped according to symptom duration (group 1: 0-3 days; group 2: 4-7 days; and group 3: 8-30 days) to compare biomarker levels.
Results: The CRP, NLR, and PLR were significantly higher in the CVST group (p < 0.001; p = 0.003; p = 0.014 respectively). The NLR and PLR presented a significant positive correlation with the CVST-Score (p = 0.003, r = 0.464; p = 0.040, r = 0.326 respectively). The NLR was significantly higher in group 1 compared with groups 2 and 3 (p = 0.016 and p = 0.014 respectively). In group 1, there was a stronger positive correlation between the CVST-Score and the NLR (p = 0.026, r = 0.591) and the PLR (p = 0.012, r = 0.648). The multiple linear regression analysis revealed that the NLR is a key factor in predicting the CVST-Score (p = 0.019).
Conclusion: The NLR and PLR are associated with thrombus burden in CVST, especially in patients admitted to the hospital in the early stages. The NLR is an independent factor to predict the thrombus burden in CVST.
期刊介绍:
Arquivos de Neuro-Psiquiatria is the official journal of the Brazilian Academy of Neurology. The mission of the journal is to provide neurologists, specialists and researchers in Neurology and related fields with open access to original articles (clinical and translational research), editorials, reviews, historical papers, neuroimages and letters about published manuscripts. It also publishes the consensus and guidelines on Neurology, as well as educational and scientific material from the different scientific departments of the Brazilian Academy of Neurology.
The ultimate goals of the journal are to contribute to advance knowledge in the areas of Neurology and Neuroscience, and to provide valuable material for training and continuing education for neurologists and other health professionals working in the area. These goals might contribute to improving care for patients with neurological diseases. We aim to be the best Neuroscience journal in Latin America within the peer review system.