与膀胱癌卡介苗（BCG）治疗相关的表观遗传学变化。

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-26 DOI:10.1016/j.bbcan.2024.189123

Lucy C. Picard, Fenella J. Rich, Diane N. Kenwright, Aaron J. Stevens

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引用次数: 0

摘要

卡介苗（BCG）治疗非肌层浸润性膀胱癌（NMIBC）是一种成熟的免疫疗法，但相当一部分患者对治疗没有反应。尽管对卡介苗的治疗机制进行了广泛研究，但我们的认识仍然存在差距。本综述特别关注卡介苗治疗 NMIBC 时免疫微环境中表观基因组的作用。我们还总结了目前对 NMIBC 表观基因特征的理解，并讨论了未来的卡介苗治疗靶向策略应如何将表观基因组生物标记与基因组生物标记结合起来。

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Epigenetic changes associated with Bacillus Calmette-Guerin (BCG) treatment in bladder cancer

Bacillus Calmette-Guérin (BCG) treatment for non-muscle invasive bladder cancer (NMIBC) is an established immunotherapeutic, however, a significant portion of patients do not respond to treatment. Despite extensive research into the therapeutic mechanism of BCG, gaps remain in our understanding. This review specifically focuses on the epigenomic contributions in the immune microenvironment, in the context of BCG treatment for NMIBC. We also summarise the current understanding of NMIBC epigenetic characteristics, and discuss how future targeted strategies for BCG therapy should incorporate epigenomic biomarkers in conjunction with genomic biomarkers.

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.