ISR 途径对线粒体疾病组织特异性的贡献。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-10-01 Epub Date: 2024-05-27 DOI:10.1016/j.tem.2024.05.001

Ana Vela-Sebastián, Pilar Bayona-Bafaluy, David Pacheu-Grau

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引用次数: 0

摘要

全身突变导致的线粒体基因缺陷通常会以不同的方式影响不同的组织。阐明导致某些细胞类型主要受影响的分子决定因素已成为该领域的一个重要研究目标。我们提出，综合应激反应的不同激活方式是造成这种组织特异性的潜在因素。

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ISR pathway contribution to tissue specificity of mitochondrial diseases.

Mitochondrial genetic defects caused by whole-body mutations typically affect different tissues in different ways. Elucidating the molecular determinants that cause certain cell types to be primarily affected has become a critical research target within the field. We propose a differential activation of the integrated stress response as a potential contributor to this tissue specificity.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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