消化系统肿瘤器官组织研究的革命性突破:探索肿瘤器官组织的潜力。

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING
Journal of Tissue Engineering Pub Date : 2024-05-27 eCollection Date: 2024-01-01 DOI:10.1177/20417314241255470
Zhian Xiu, Qian Yang, Fusheng Xie, Feng Han, Weiwei He, Weifang Liao
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引用次数: 0

摘要

消化系统肿瘤是导致全球癌症相关死亡的主要原因。尽管研究仍在进行,但我们对其发病机制和治疗方法的了解仍然不足。胃肠道肿瘤器官组织是一种很有前景的临床应用工具,它是一种重要的体外模型。肿瘤器官组织表现出与患者肿瘤相似的基因型,能有效模拟各种生物过程,包括组织更新、干细胞和生态位功能,以及组织对药物、突变或损伤的反应。因此,它们在药物筛选、开发新型药物、评估患者预后和支持免疫疗法方面具有重要价值。此外,创新材料和技术可用于优化肿瘤类器官培养系统。消化系统肿瘤类器官的一些应用已被描述,并在相关方面取得了可喜的成果。在这篇综述中,我们将讨论这一消化系统肿瘤模型的当前进展、局限性和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Revolutionizing digestive system tumor organoids research: Exploring the potential of tumor organoids.

Digestive system tumors are the leading cause of cancer-related deaths worldwide. Despite ongoing research, our understanding of their mechanisms and treatment remain inadequate. One promising tool for clinical applications is the use of gastrointestinal tract tumor organoids, which serve as an important in vitro model. Tumor organoids exhibit a genotype similar to the patient's tumor and effectively mimic various biological processes, including tissue renewal, stem cell, and ecological niche functions, and tissue response to drugs, mutations, or injury. As such, they are valuable for drug screening, developing novel drugs, assessing patient outcomes, and supporting immunotherapy. In addition, innovative materials and techniques can be used to optimize tumor organoid culture systems. Several applications of digestive system tumor organoids have been described and have shown promising results in related aspects. In this review, we discuss the current progress, limitations, and prospects of this model for digestive system tumors.

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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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