早产儿和足月儿母体龈下微生物群的差异:MOHEPI 研究。

IF 3.4 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Jung Soo Park, Eunha Kim, Sun Jae Kwon, Ju Sun Heo, Ki Hoon Ahn
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引用次数: 0

摘要

目的:牙周炎是女性早产(PTB)的潜在风险因素,但其因果关系或确切机制仍不清楚。本研究旨在比较足月产(FTB)母亲和早产母亲的口腔微生物组特征:本研究前瞻性地纳入了 60 名产妇(30 名早产产妇和 30 名足月产产妇),收集了龈下菌斑样本,并通过元基因组 16S rDNA 测序进行了分析。临床测量包括牙周探诊深度、临床附着水平、改良牙龈指数(mGI)和牙菌斑指数,以确定参与者的牙周状况。此外,还收集了医疗和产科数据:在牙周测量中,反映牙龈炎症程度的 mGI 评分与 PTB 有显著的统计学关联(调整后的几率比 2.705,95% 置信区间 1.074-6.811,p = .035)。如果根据 mGI 平均得分进行亚组分析(mGI ≥ 2,高炎症 [HI] 与 mGI 结论相比,高炎症 [HI] 与 mGI 结论相比,高炎症 [HI] 与 mGI 结论相比,高炎症 [HI] 与 mGI 结论相比),结果表明,母体牙龈下微生物的组成与 PTB 有明显的相关性:在高低牙龈炎症水平组中,PTB 和 FTB 母亲的龈下微生物组的组成存在差异。在牙龈炎症水平较高的情况下,就牙周炎而言,PTB 母亲牙菌斑微生物组中的菌群失调比 FTB 母亲少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Differences in maternal subgingival microbiome between preterm and term births: The MOHEPI study

Differences in maternal subgingival microbiome between preterm and term births: The MOHEPI study

Aim

Periodontitis is a potential risk factor for preterm birth (PTB) in women; however, the causal relationship or the exact mechanism remain unknown. This study aimed to compare the oral microbiome features of mothers with full-term birth (FTB) with those who had preterm delivery.

Methods

This study prospectively enrolled 60 women (30 mothers with PTB and 30 mothers with FTB), and subgingival plaque samples were collected and analysed by metagenomic 16S rDNA sequencing. Clinical measurements, including periodontal probing depth, clinical attachment level, modified gingival index (mGI) and plaque index, were performed to determine the periodontal state of the participants. Medical and obstetric data were collected as well.

Results

Among the periodontal measurements, mGI score, reflecting the level of gingival inflammation, exhibited a statistically significant association with PTB (adjusted odds ratio 2.705, 95% confidence interval 1.074–6.811, p = .035). When subgroup analysis was conducted based on mean mGI scores (mGI ≥ 2, high inflammation [HI] versus mGI < 2, low inflammation [LI]), microbiome analysis revealed clear distinctions in microbial compositions between PTB and FTB mothers in both the HI and LI groups. Especially in the HI group, alpha diversity exhibited a decreasing trend in PTB mothers compared to FTB mothers. Beta diversity also revealed significant differences between the two groups. In Linear Discriminant Analysis Effect Size analysis, certain anaerobic taxa, including the genera Spirochaetes, Treponema and Porphyromonas, were relatively abundant in the FTB/HI group, whereas the PTB/HI group showed a high abundance of the order Actinomycetales. Network analysis showed that the FTB/HI had relatively stronger connectivity in microbial composition than the PTB/HI group. Dysbiosis ratio of plaque microbiome, in terms of periodontitis, was significantly lower in PTB/HI group compared to FTB/HI group.

Conclusion

The compositions of maternal subgingival microbiomes differed between PTB and FTB mothers in both the high and low levels of gingival inflammation groups. In the presence of high level of gingival inflammation, dysbiosis in plaque microbiome, in terms of periodontitis, was decreased in PTB mothers compared to FTB mothers.

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来源期刊
Journal of periodontal research
Journal of periodontal research 医学-牙科与口腔外科
CiteScore
6.90
自引率
5.70%
发文量
103
审稿时长
6-12 weeks
期刊介绍: The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.
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