对淀粉代谢酶及其应用的结构研究。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-22 DOI:10.1093/bbb/zbae069

Takayoshi Tagami

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引用次数: 0

摘要

淀粉是一种多糖，只通过植物和藻类的光合作用产生；但从微生物到高等生物，大多数生物都将淀粉用作能量来源。在哺乳动物和植物发芽的种子中，淀粉通过简单的水解途径进行代谢。此外，在一些细菌中还发现了通过独特的低聚糖进行淀粉代谢的途径。每种生物都进化出了负责淀粉代谢的酶，它们的酶特性各不相同。本综述以真核生物的α-葡萄糖苷酶和细菌的α-葡萄糖苷水解酶为重点，总结了属于苷水解酶家族 15、31 和 77 的淀粉代谢酶的结构及其在寡糖生产中的应用。

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Structural insights into starch-metabolizing enzymes and their applications.

Starch is a polysaccharide produced exclusively through photosynthesis in plants and algae; however, is utilized as an energy source by most organisms, from microorganisms to higher organisms. In mammals and the germinating seeds of plants, starch is metabolized by simple hydrolysis pathways. Moreover, starch metabolic pathways via unique oligosaccharides have been discovered in some bacteria. Each organism has evolved enzymes responsible for starch metabolism that are diverse in their enzymatic properties. This review, focusing on eukaryotic α-glucosidases and bacterial α-glucoside-hydrolyzing enzymes, summarizes the structural aspects of starch-metabolizing enzymes belonging to glycoside hydrolase families 15, 31, and 77 and their application for oligosaccharide production.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.