贝赫切特综合征的性别差异:通过聚类分析确定不同的表型。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2024-10-01 Epub Date: 2024-05-29 DOI:10.1007/s12026-024-09498-1
Gamze Kılıç, Kemal Faruk Körüklü, Muhammed Galip Kumcu, Elif Çakır, Murat Karkucak, Erkan Kılıç
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引用次数: 0

摘要

贝赫切特综合征(BS)是一种复杂的多系统疾病,在全球均有发生,主要集中在丝绸之路沿线。本研究旨在调查土耳其东黑海地区白塞氏综合征患者的性别表现和临床表型。研究对 2013 年 1 月至 2023 年 12 月期间的 290 名 BS 患者进行了回顾性分析。人口统计学特征、临床表现、药物治疗和血清学检查结果均来自病历回顾。平均年龄为 45.79±13.05 岁,男女比例为 48.6:51.4。男性患者的丘疹脓疱病变率较高(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Gender disparities in Behçet's syndrome: identifying distinct phenotypes through cluster analysis.

Gender disparities in Behçet's syndrome: identifying distinct phenotypes through cluster analysis.

Behçet's syndrome (BS) is a complex, multi-systemic disorder with a global occurrence, notably concentrated along the Silk Road. This study aimed to investigate gender-specific expressions and clinical phenotypes in BS patients within the Eastern Black Sea Region of Turkey. A total of 290 BS patients were retrospectively analyzed between January 2013 and December 2023. Demographic characteristics, clinical manifestations, medical treatment, and pathergy test results were obtained from a review of medical records. The mean age was 45.79 ± 13.05, with a male-to-female ratio of 48.6:51.4. Male patients had higher papulopustular lesions (p < 0.001) and ocular involvement (p = 0.036), while females showed more frequent genital ulcers (p = 0.032). Medication usage showed gender-based variations, notably higher corticosteroid, azathioprine, and tumor necrosis factor-alpha inhibitor (TNFi) use in males (p < 0.001). Cluster analysis revealed five distinct clusters, each with unique features and gender predominance. Cardiovascular type, ocular type, and skin type predominantly featured male patients, while joint involvement type and neurologic and mucosal involvement type were more prevalent among female patients with BS. This research contributes valuable insights into the gender-related clinical variations of BS within a specific geographic region, fostering a more comprehensive understanding of this challenging syndrome. The identification of distinct clinical phenotypes facilitates the development of tailored treatment strategies, potentially leading to improved outcomes for patients with BS.

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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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