慢性高血压会改变侧支血流、大脑皮层血流和脑组织氧合之间的关系。

IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Ryan D Hunt, Marilyn J Cipolla
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引用次数: 0

摘要

本研究测量了急性缺血性脑卒中期间皮质侧支(脑外膜吻合处,LMA)血流、实质内皮质脑血流(cCBF)和脑组织氧合(btO2)之间的关系,以研究皮质血流如何转化为下游的 cCBF 和 btO2,并探讨高血压如何改变这种关系。研究人员对雄性 Wistar 大鼠(8 只/组)和自发性高血压大鼠(SHR,8 只/组)进行了近端瞬时大脑中动脉闭塞(tMCAO)。除了测量 LMA 流量的表面激光多普勒探头外,还在预期的皮质梗死周围放置了激光多普勒-氧气组合探头。在 tMCAO 30 分钟后输注苯肾上腺素(PE),使血压(BP)升高 30%,持续 10 分钟,并评估 CBF 的自动调节。在 tMCAO 的最初 30 分钟内,SHR 的 btO2 和 cCBF 均低于 Wistar 大鼠(btO2:11.5 ± 10.5 vs 17.5 ± 10.8 mmHg,cCBF:-29.7 ± 23.3% vs -17.8 ± 41.9%);但各组之间的 LMA 流量相似。在 Wistar 大鼠中,LMA 流量、cCBF 和 btO2 之间的关系是相互依存的。然而,这种关系在 SHR 大鼠中被破坏,并通过诱导性高血压得到部分恢复。本研究提供的证据表明,慢性高血压患者在 tMCAO 期间 cCBF 和 btO2 会降低,而无论高血压状态如何,诱导性高血压都是有益的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic hypertension alters the relationship between collateral blood flow cortical cerebral blood flow, and brain tissue oxygenation.

This study measured the relationship between pial collateral (leptomeningeal anastomoses, LMA) flow, intraparenchymal cortical cerebral blood flow (cCBF) and brain tissue oxygenation (btO2) during acute ischemic stroke to investigate how pial flow translates to downstream cCBF and btO2 and examined how this relationship is altered in hypertension. Proximal transient middle cerebral artery occlusion (tMCAO) was performed in male Wistar (n = 8/group) and Spontaneously Hypertensive Rats (SHR, n = 8/group). A combination laser Doppler-oxygen probe was placed within the expected cortical peri-infarct in addition to a surface laser doppler probe which measured LMA flow. Phenylephrine (PE) was infused 30 minutes into tMCAO to increase blood pressure (BP) by 30% for 10 minutes and assessed CBF autoregulation. During the initial 30-minute period of tMCAO, btO2 and cCBF were lower in SHR compared to Wistar rats (btO2: 11.5 ± 10.5 vs 17.5 ± 10.8 mmHg and cCBF: -29.7 ± 23.3% vs -17.8 ± 41.9%); however, LMA flow was similar between groups. The relationship between LMA flow, cCBF and btO2 were interdependent in Wistar rats. However, this relationship was disrupted in SHR rats and partially restored by induced hypertension. This study provides evidence that cCBF and btO2 were diminished during tMCAO in chronic hypertension, and that induced hypertension was beneficial regardless of hypertensive status.

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来源期刊
Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.80%
发文量
300
审稿时长
3 months
期刊介绍: JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.
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