爱泼斯坦-巴氏病毒阳性的脾脏炎性滤泡树突状细胞肉瘤临床病理分析：病例报告。

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Annals of clinical and laboratory science Pub Date : 2024-03-01

Yi-Hui Yang, Hong-Qi Shi, Jia-Wei Cai, Sheng-Kai Wang

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引用次数: 0

摘要

研究目的本研究旨在探讨 Epstein-Barr 病毒（EBV）阳性炎性滤泡树突状细胞肉瘤（IFDCS；EBV+ IFDCS）的临床病理特征：该病例涉及一名 32 岁女性，她接受了脾脏结节的手术切除。采用分化簇（CD）标记物进行了组织学检查和免疫组化，并进行了原位杂交以检测EBV编码的RNA（EBER）：显微镜分析显示，肿瘤细胞形态各异，有圆形、卵圆形或纺锤形，分散在突出的淋巴浆细胞浸润中。肿瘤细胞表现出核不典型性，其中一些细胞类似于里德-斯特恩伯格细胞（Reed-Sternberg cells）。免疫组化结果显示，CD21、CD23 和 CD35 等滤泡树突状细胞标志物呈局灶性阳性，而 CD3、CD34、CD20、CD79a、髓过氧化物酶和 HMB45 等其他标志物呈局灶性阴性。此外，EBER 染色结果呈强阳性。在13个月的随访中，患者没有出现局部复发或转移：结论：全面了解 EBV+IFDCS，包括其临床病理特征和免疫组化特征，对于这种罕见肿瘤的准确诊断和鉴别诊断至关重要。

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本刊更多论文

Clinicopathological Analysis of Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma of the Spleen: A Case Report.

Objective: The present study aims to explore the clinicopathological characteristics of Epstein-Barr virus (EBV)-positive inflammatory follicular dendritic cell sarcoma (IFDCS; EBV+ IFDCS).

Case report: The case involved a 32-year-old woman who underwent surgical resection of a splenic nodule. Histological examination and immunohistochemistry were performed using cluster of differentiation (CD) markers, and in-situ hybridization was conducted to detect EBV-encoded RNA (EBER).

Results: A microscopic analysis revealed neoplastic cells with various morphologies, including round, ovoid, or spindled shapes, dispersed within a prominent lymphoplasmacytic infiltrate. The tumor cells exhibited nuclear atypia, with some resembling Reed-Sternberg cells. The immunohistochemistry demonstrated focal positivity for follicular dendritic cell markers, such as CD21, CD23 and CD35, and focal negativity for other markers, including CD3, CD34, CD20, CD79a, myeloperoxidase and HMB45. Additionally, the EBER staining showed strongly positive results. The patient showed no local recurrence or metastasis during the 13-month follow-up.

Conclusion: A comprehensive understanding of EBV+IFDCS, including its clinicopathological features and immunohistochemical characteristics, is crucial for accurate diagnosis and differential diagnosis of this rare tumor.

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来源期刊

Annals of clinical and laboratory science 医学-医学实验技术

CiteScore

1.60

自引率

0.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： The Annals of Clinical & Laboratory Science welcomes manuscripts that report research in clinical science, including pathology, clinical chemistry, biotechnology, molecular biology, cytogenetics, microbiology, immunology, hematology, transfusion medicine, organ and tissue transplantation, therapeutics, toxicology, and clinical informatics.