[血液炎症综合指数与 I 期尘肺病及其合并肺部感染的关系]。

Q3 Medicine
Y J Diao, J N Hua, L Xu, Q Wu
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引用次数: 0

摘要

目的分析 I 期尘肺并发肺部感染患者的血液炎症综合指数,探讨其在预测患者病情方面的价值。方法选取2021年11月至2023年8月在天津市职业病防治院接受治疗的83例I期尘肺患者,根据是否合并肺部感染分为非感染组(56例)和感染组(27例)。选择同期有粉尘接触史但未被诊断为尘肺病的工人作为对照组(65 例)。通过查阅病历,收集性别、年龄、职业史、既往病史、血液学检查等临床资料,比较三组血液综合炎症指标的差异,绘制ROC曲线,分析血液综合炎症指标与尘肺一期及其合并肺部感染的关系。结果中性粒细胞数(N)、淋巴细胞数(L)、单核细胞数(M)、C反应蛋白(CRP)、中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)、血小板与淋巴细胞比值(PLR)均有显著差异、全身免疫炎症指数(SII)、全身炎症反应指数(SIRI)、全身炎症综合指数(AISI)、衍生中性粒细胞与淋巴细胞比率(dNLR)、中性粒细胞与淋巴细胞和血小板比率(NLPR)以及 C 反应蛋白与淋巴细胞比率(CLR)(PPPPPCI:0.NLR、MLR、C-反应蛋白与淋巴细胞比值(PPPPPCI:0.710-0.873)的临界值为 0.18,灵敏度为 71.4%,特异度为 78.5%。NLR、MLR、PLR、SII、SIRI、AISI、dNLR、NLPR 和 CLR 对尘肺一期合并肺部感染均有一定的预测能力(PCI:0.824~0.985),临界值为 5.33,敏感性为 77.8%,特异性为 98.2%。结论血液炎症综合指数可作为尘肺一期及其合并肺部感染的辅助预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The relationship between the comprehensive blood inflammation indexes and stage I pneumoconiosis and its combined lung infections].

Objective: To analyze the comprehensive blood inflammation index of the patients with stage I pneumoconiosis complicated with pulmonary infection, and to explore its value in predicting the patients' disease. Methods: In September 2023, 83 patients with stage I pneumoconiosis who were treated in Tianjin Occupational Diseases Precaution and Therapeutic Hospital from November 2021 to August 2023 were selected and divided into non-infected group (56 cases) and infected group (27 cases) according to whether they were combined with lung infection. Workers with a history of dust exposure but diagnosed without pneumoconiosis during the same period were selected as the control group (65 cases) . By referring to medical records and collecting clinical data such as gender, age, occupational history, past medical history, hematology testing, the differences in the comprehensive blood inflammation indexes among the three groups were compared, ROC curve was drawn, and the relationship between comprehensive blood inflammation indexes and stage I pneumoconiosis and its combined lung infection was analyzed. Results: There were significtant differences in the number of neutrophils (N) , the number of lymphocytes (L) , the number of monocytes (M) , C-reactive protein (CRP) , the neutrophil to lymphocyte ratio (NLR) , the monocyte to lymphocyte ratio (MLR) , the platelet to lymphocyte ratio (PLR) , the systemic immune-inflammatory index (SII) , the systemic inflammation response index (SIRI) , the aggregate index of systemic inflammation (AISI) , the derived neutrophil to lymphocyte ratio (dNLR) , the neutrophil to lymphocyte and platelet ratio (NLPR) , and the C-reactive protein to lymphocyte ratio (CLR) (P<0.05) . Compared with the control group, MLR, SIRI and AISI in the non-infected group were significantly increased (P<0.05) . NLR, MLR, PLR, SII, SIRI, AISI, dNLR, NLPR, CLR were significantly increased (P<0.05) . Compared with the non-infected group, NLR, PLR, SII, SIRI, AISI, dNLR, NLPR and CLR were significantly increased in the infected group (P<0.05) . ROC analysis showed that NLR, MLR, PLR, SII, SIRI and AISI had a certain predictive capability for stage I pneumoconiosis (P<0.05) , among which MLR had the highest efficacy, with an AUC of 0.791 (95% CI: 0.710-0.873) , the cut-off value was 0.18, the sensitivity was 71.4%, and the specificity was 78.5%. NLR, MLR, PLR, SII, SIRI, AISI, dNLR, NLPR and CLR all had a certain predictive capability forstage I pneumoconiosis combined lung infection (P<0.05) , among which CLR had the highest efficacy, with an AUC of 0.904 (95%CI: 0.824~0.985) , the cut-off value was 5.33, sensitivity was 77.8%, specificity was 98.2%. Conclusion: The comprehensive blood inflammation index may be an auxiliary predictor of stage I pneumoconiosis and its combined lung infections.

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中华劳动卫生职业病杂志
中华劳动卫生职业病杂志 Medicine-Medicine (all)
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