Andrea M. Brennan, Paul M. Coen, Theresa Mau, Megan Hetherington-Rauth, Frederico G. S. Toledo, Erin E. Kershaw, Peggy M. Cawthon, Philip A. Kramer, Sofhia V. Ramos, Anne B. Newman, Steven R. Cummings, Daniel E. Forman, Reichelle X. Yeo, Giovanna Distefano, Iva Miljkovic, Jamie N. Justice, Anthony J. A. Molina, Michael J. Jurczak, Lauren M. Sparks, Stephen B. Kritchevsky, Bret H. Goodpaster
{"title":"老年男性和女性区域脂肪组织分布与骨骼肌生物能之间的关系。","authors":"Andrea M. Brennan, Paul M. Coen, Theresa Mau, Megan Hetherington-Rauth, Frederico G. S. Toledo, Erin E. Kershaw, Peggy M. Cawthon, Philip A. Kramer, Sofhia V. Ramos, Anne B. Newman, Steven R. Cummings, Daniel E. Forman, Reichelle X. Yeo, Giovanna Distefano, Iva Miljkovic, Jamie N. Justice, Anthony J. A. Molina, Michael J. Jurczak, Lauren M. Sparks, Stephen B. Kritchevsky, Bret H. Goodpaster","doi":"10.1002/oby.24008","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>The aim of this study was to examine associations of ectopic adipose tissue (AT) with skeletal muscle (SM) mitochondrial bioenergetics in older adults.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Cross-sectional data from 829 adults ≥70 years of age were used. Abdominal, subcutaneous, and visceral AT and thigh muscle fat infiltration (MFI) were quantified by magnetic resonance imaging. SM mitochondrial energetics were characterized <i>in vivo</i> (<sup>31</sup>P-magnetic resonance spectroscopy; ATP<sub>max</sub>) and <i>ex vivo</i> (high-resolution respirometry maximal oxidative phosphorylation [OXPHOS]). ActivPal was used to measure physical activity ([PA]; step count). Linear regression adjusted for covariates was applied, with sequential adjustment for BMI and PA.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Independent of BMI, total abdominal AT (standardized [Std.] <i>β</i> = −0.21; <i>R</i><sup>2</sup> = 0.09) and visceral AT (Std. <i>β</i> = −0.16; <i>R</i><sup>2</sup> = 0.09) were associated with ATP<sub>max</sub> (<i>p</i> < 0.01; <i>n</i> = 770) but not following adjustment for PA (<i>p</i> ≥ 0.05; <i>n</i> = 658). Visceral AT (Std. <i>β</i> = −0.16; <i>R</i><sup>2</sup> = 0.25) and thigh MFI (Std. <i>β</i> = −0.11; <i>R</i><sup>2</sup> = 0.24) were associated with carbohydrate-supported maximal OXPHOS independent of BMI and PA (<i>p</i> < 0.05; <i>n</i> = 609). Total abdominal AT (Std. <i>β</i> = −0.19; <i>R</i><sup>2</sup> = 0.24) and visceral AT (Std. <i>β</i> = −0.17; <i>R</i><sup>2</sup> = 0.24) were associated with fatty acid-supported maximal OXPHOS independent of BMI and PA (<i>p</i> < 0.05; <i>n</i> = 447).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Skeletal MFI and abdominal visceral, but not subcutaneous, AT are inversely associated with SM mitochondrial bioenergetics in older adults independent of BMI. Associations between ectopic AT and <i>in vivo</i> mitochondrial bioenergetics are attenuated by PA.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24008","citationCount":"0","resultStr":"{\"title\":\"Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women\",\"authors\":\"Andrea M. Brennan, Paul M. Coen, Theresa Mau, Megan Hetherington-Rauth, Frederico G. S. Toledo, Erin E. Kershaw, Peggy M. Cawthon, Philip A. Kramer, Sofhia V. Ramos, Anne B. Newman, Steven R. Cummings, Daniel E. Forman, Reichelle X. Yeo, Giovanna Distefano, Iva Miljkovic, Jamie N. Justice, Anthony J. A. Molina, Michael J. Jurczak, Lauren M. Sparks, Stephen B. Kritchevsky, Bret H. Goodpaster\",\"doi\":\"10.1002/oby.24008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>The aim of this study was to examine associations of ectopic adipose tissue (AT) with skeletal muscle (SM) mitochondrial bioenergetics in older adults.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Cross-sectional data from 829 adults ≥70 years of age were used. Abdominal, subcutaneous, and visceral AT and thigh muscle fat infiltration (MFI) were quantified by magnetic resonance imaging. SM mitochondrial energetics were characterized <i>in vivo</i> (<sup>31</sup>P-magnetic resonance spectroscopy; ATP<sub>max</sub>) and <i>ex vivo</i> (high-resolution respirometry maximal oxidative phosphorylation [OXPHOS]). ActivPal was used to measure physical activity ([PA]; step count). Linear regression adjusted for covariates was applied, with sequential adjustment for BMI and PA.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Independent of BMI, total abdominal AT (standardized [Std.] <i>β</i> = −0.21; <i>R</i><sup>2</sup> = 0.09) and visceral AT (Std. <i>β</i> = −0.16; <i>R</i><sup>2</sup> = 0.09) were associated with ATP<sub>max</sub> (<i>p</i> < 0.01; <i>n</i> = 770) but not following adjustment for PA (<i>p</i> ≥ 0.05; <i>n</i> = 658). Visceral AT (Std. <i>β</i> = −0.16; <i>R</i><sup>2</sup> = 0.25) and thigh MFI (Std. <i>β</i> = −0.11; <i>R</i><sup>2</sup> = 0.24) were associated with carbohydrate-supported maximal OXPHOS independent of BMI and PA (<i>p</i> < 0.05; <i>n</i> = 609). Total abdominal AT (Std. <i>β</i> = −0.19; <i>R</i><sup>2</sup> = 0.24) and visceral AT (Std. <i>β</i> = −0.17; <i>R</i><sup>2</sup> = 0.24) were associated with fatty acid-supported maximal OXPHOS independent of BMI and PA (<i>p</i> < 0.05; <i>n</i> = 447).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Skeletal MFI and abdominal visceral, but not subcutaneous, AT are inversely associated with SM mitochondrial bioenergetics in older adults independent of BMI. Associations between ectopic AT and <i>in vivo</i> mitochondrial bioenergetics are attenuated by PA.</p>\\n </section>\\n </div>\",\"PeriodicalId\":215,\"journal\":{\"name\":\"Obesity\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24008\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/oby.24008\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24008","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women
Objective
The aim of this study was to examine associations of ectopic adipose tissue (AT) with skeletal muscle (SM) mitochondrial bioenergetics in older adults.
Methods
Cross-sectional data from 829 adults ≥70 years of age were used. Abdominal, subcutaneous, and visceral AT and thigh muscle fat infiltration (MFI) were quantified by magnetic resonance imaging. SM mitochondrial energetics were characterized in vivo (31P-magnetic resonance spectroscopy; ATPmax) and ex vivo (high-resolution respirometry maximal oxidative phosphorylation [OXPHOS]). ActivPal was used to measure physical activity ([PA]; step count). Linear regression adjusted for covariates was applied, with sequential adjustment for BMI and PA.
Results
Independent of BMI, total abdominal AT (standardized [Std.] β = −0.21; R2 = 0.09) and visceral AT (Std. β = −0.16; R2 = 0.09) were associated with ATPmax (p < 0.01; n = 770) but not following adjustment for PA (p ≥ 0.05; n = 658). Visceral AT (Std. β = −0.16; R2 = 0.25) and thigh MFI (Std. β = −0.11; R2 = 0.24) were associated with carbohydrate-supported maximal OXPHOS independent of BMI and PA (p < 0.05; n = 609). Total abdominal AT (Std. β = −0.19; R2 = 0.24) and visceral AT (Std. β = −0.17; R2 = 0.24) were associated with fatty acid-supported maximal OXPHOS independent of BMI and PA (p < 0.05; n = 447).
Conclusions
Skeletal MFI and abdominal visceral, but not subcutaneous, AT are inversely associated with SM mitochondrial bioenergetics in older adults independent of BMI. Associations between ectopic AT and in vivo mitochondrial bioenergetics are attenuated by PA.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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