揭示自噬在人类牙髓中的作用。

Q3 Medicine

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-01-01 Epub Date: 2024-04-15 DOI:10.4103/jomfp.jomfp_197_23

Tulika Wakhloo, Sanjeev Kishore, Prashant Durgapal

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引用次数: 0

摘要

自噬是一种进化保守的细胞内分解代谢过程，可回收和降解蛋白质、细胞器和病原体。自噬是一种内源性防御机制，可调节多种细胞通路，如细胞凋亡、炎症、免疫反应和病原体清除，是发病机制的调节器。本文强调了自噬在炎症和人类牙髓再生中的新作用。文章强调，自噬和自噬激动剂是开发新型治疗干预措施的潜在靶点。

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Unravelling the role of autophagy in human dental pulp.

Autophagy is an evolutionarily conserved intracellular catabolic process that recycles and degrades proteins, organelles and pathogens. It is an endogenous defence mechanism regulating multiple cellular pathways like apoptosis, inflammation, immune response and pathogen clearance and acts as a modulator of pathogenesis. This article highlights the emerging role of autophagy in inflammation and regeneration of human dental pulp. It emphasizes exploring autophagy and autophagy agonists as potential targets for the development of novel therapeutic interventions.

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来源期刊

Journal of Oral and Maxillofacial Pathology Medicine-Otorhinolaryngology

CiteScore

1.40

自引率

0.00%

发文量

115

期刊介绍： The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.