季节、户籍与孤立性出生缺陷：中国丹阳的一项基于人群的病例对照研究。

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Health Pub Date : 2024-09-05 DOI:10.1093/inthealth/ihae034

Shuhan Miao, Liqun Liu, Yanlin Tang, Hongyan Ge

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引用次数: 0

摘要

背景我们在江苏省丹阳市开展了一项基于出生人口的研究，以评估在孕产妇和新生儿护理条件相似的中国新兴地区的主要出生缺陷：我们对2014年至2021年期间在丹阳出生的55 709名围产期婴儿进行了一项基于人群的研究。四类孤立性出生缺陷被定义为病例：先天性心脏缺陷（CHDs；n=2138）、多指畸形（n=145）、唇裂伴或不伴腭裂（CL/P；n=76）和附属耳廓（n=93）。中国出生缺陷监测网对患有先天性畸形的婴儿进行了鉴定：与秋季相比，春季（OR=1.31 [1.16-1.48]）和冬季（OR=1.39 [1.23-1.58]）受孕与先天性心脏病风险增加有关。CHD、CL/P 和附属耳廓的风险增加与非本地户籍居住地显著相关（OR=1.17 [1.07-1.28]、OR=2.73 [1.52-4.88] 和 OR=2.11 [1.20-3.71]）。汉族人患多指畸形的几率较低（OR=0.23 [0.05-0.98]）：结论：怀孕季节与先天性心脏病密切相关。结论：妊娠季节与先天性心脏病显著相关，非本地户籍母亲的后代患先天性心脏病、CL/P 和副耳的风险更高。

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Season, household registry and isolated birth defects: a population-based case-control study in Danyang, China.

Background: A birth population-based study was conducted in Danyang, Jiangsu Province, to evaluate major birth defects in emerging regions in China with similar maternal and neonatal care conditions.

Methods: We conducted a population-based study in a cohort of infants born in Danyang from 2014 to 2021, including 55 709 perinatal infants. Four categories of isolated birth defects were defined as cases: congenital heart defects (CHDs; n=2138), polydactyly (n=145), cleft lip with or without palate (CL/P; n=76) and accessory auricles (n=93). Infants with congenital malformations were identified by the Chinese Birth Defects Monitoring Network.

Results: Compared with autumn, conception in spring (OR=1.31 [1.16-1.48]) and winter (OR=1.39 [1.23-1.58]) was associated with an increased risk of CHD. Increased risk of CHD, CL/P and accessory auricles was significantly associated with non-local registered residence (OR=1.17 [1.07-1.28], OR=2.73 [1.52-4.88] and OR=2.11 [1.20-3.71], respectively). Individuals of Han nationality were less likely to have polydactyly (OR=0.23 [0.05-0.98]).

Conclusions: The season of pregnancy was significantly associated with CHDs. Offspring of mothers with non-local registered hometown had greater risks of CHDs, CL/P and accessory auricles.

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来源期刊

International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.