评估社交孤立和孤独感的变化与心血管事件和死亡率的关系。

IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Yilin Chen, Huachen Xue, Yu Nie, Yujing Zhou, Sizhi Ai, Yaping Liu, Jihui Zhang, Yannis Yan Liang
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引用次数: 0

摘要

背景:社会隔离和孤独感的变化规律与心血管疾病(CVD)的发病和死亡率有何关联,目前仍是未知数。我们的目的是调查社会隔离和孤独感的变化与心血管疾病发病、全因死亡率、心血管疾病死亡率和后续心脏功能的纵向联系:这项前瞻性队列研究纳入了 18258 名年龄在 38-73 岁之间的参与者,他们通过英国生物数据库参与了第 0 次访问(2006-2010 年)和第 1 次访问(2012-2013 年)(平均年龄 57.1 岁,标准差 [SD] 7.4;48.7% 为男性)。社会隔离或孤独分为四种模式:从不、短暂、偶发和持续。通过关联数据确定了心血管疾病发病率、全因死亡率和心血管疾病死亡率。通过心血管磁共振成像对一个子样本(N = 5188;访问 2,自 2014 年起)的心脏功能进行了评估:在中位随访 8.3 年(四分位距[IQR] 8.1-8.6)期间,与从未有过社会隔离的人相比,持续的社会隔离与较高的心血管疾病发病风险(危险比 [HR] 1.17,95% 置信区间 [CI] 1.03-1.33)、全因(1.42,1.12-1.81)和心血管疾病(1.53,1.05-2.23)死亡率相关。同样,持续的孤独感也与心血管疾病(1.13,1.00-1.27)、全因(1.28,1.02-1.61)和心血管疾病(1.52,1.06-2.18)死亡风险的增加密切相关:与其他模式相比,持续的社会隔离和孤独对心血管疾病、全因和心血管疾病死亡率以及心脏功能障碍的发生具有更高的风险。持续的社会隔离和孤独感以及累积分数的增加与心功能减退有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Changes in Social Isolation and Loneliness with Incident Cardiovascular Events and Mortality.

Background: It remains unknown how the patterns of change of social isolation and loneliness are associated with the onset of cardiovascular disease (CVD) and mortality. We aimed to investigate the longitudinal association of changes in social isolation and loneliness with incident CVD, all-cause mortality, CVD mortality and subsequent cardiac function.

Methods: This prospective cohort study included 18,258 participants aged 38-73 years who participated in visit 0 (2006-2010) and visit 1 (2012-2013) using UK Biobank (mean age 57.1, standard deviation [SD] 7.4; 48.7% males). Social isolation or loneliness was categorized into four patterns: never, transient, incident, and persistent. Incident CVD, all-cause and CVD mortality were ascertained through linkage data. Cardiac function was assessed by cardiovascular magnetic resonance imaging in a subsample (N = 5188; visit 2, since 2014).

Results: Over a median follow-up of 8.3 (interquartile range [IQR] 8.1-8.6) years, compared with never social isolation, persistent social isolation was associated with the higher risk of incident CVD (hazard ratio [HR] 1.17, 95% confidence interval [CI] 1.03-1.33), all-cause (1.42, 1.12-1.81) and CVD (1.53, 1.05-2.23) mortality. Likewise, persistent loneliness was strongly associated with the greater risk of incident CVD (1.13, 1.00-1.27), all-cause (1.28, 1.02-1.61) and CVD mortality (1.52, 1.06-2.18).

Conclusions: Persistent social isolation and loneliness posed a substantially higher risk for incident CVD, all-cause and CVD mortality, and cardiac dysfunction than other patterns. Persistent social isolation and loneliness, along with an increasing cumulative score, are associated with lower cardiac function.

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来源期刊
CiteScore
10.70
自引率
1.40%
发文量
57
审稿时长
19 weeks
期刊介绍: The Journal of Epidemiology and Global Health is an esteemed international publication, offering a platform for peer-reviewed articles that drive advancements in global epidemiology and international health. Our mission is to shape global health policy by showcasing cutting-edge scholarship and innovative strategies.
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