{"title":"在侵蚀性-萎缩性口腔扁平苔藓患者中比较含有 10%黑升麻的新型粘液贴片与 0.1% 曲安奈德的疗效：试点研究。","authors":"Atessa Pakfetrat, Zahra Delavarian, Mahshid Malakooti, Hossein Bagheri, Habibollah Esmaily, Mahsa Ghorbani, Pooya Saeedi","doi":"10.1002/cre2.886","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study evaluates the efficacy of a novel mucoadhesive patch containing <i>Nigella sativa</i> 10% extract compared to triamcinolone 0.1% in alleviating symptoms and reducing lesion severity in patients with erosive-atrophic oral lichen planus.</p>\n </section>\n \n <section>\n \n <h3> Methods and Materials</h3>\n \n <p>A pilot study comprising two groups, each with 10 patients, was conducted. The intervention group received mucoadhesive patches containing <i>N. sativa</i> 10% extract, while the control group received triamcinolone acetonide 0.1% patches. Pain and burning intensity, measured through visual analog scale, and lesion severity based on the Thongprasom scale were assessed weekly for 4 weeks. Descriptive records were kept for side effects and patient satisfaction.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Pain and burning intensity decreased in both groups throughout the sessions, with the <i>N. sativa</i> group showing a greater reduction than the triamcinolone group. The reduction in burning intensity within each group was significant (<i>p</i> < .001), and there was a significant difference between groups only in the second session (<i>p</i> = .045). The overall difference between groups was not significant (<i>p</i> > .05). Lesion severity also decreased significantly in both groups (<i>p</i> < .001), with a significant difference between groups observed in the third session (<i>p</i> = .043) and overall throughout the study (<i>p</i> = .006).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The use of <i>N. sativa</i> extract in mucoadhesive patches was as effective as corticosteroids in reducing pain, burning, and lesion severity in patients with oral lichen planus, with <i>N. sativa</i> showing superior results in some sessions. Notably, no significant complications were observed with <i>N. sativa</i> use, making it a promising treatment option for lichen planus.</p>\n </section>\n </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 3","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.886","citationCount":"0","resultStr":"{\"title\":\"Comparing the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% with triamcinolone 0.1% in patients with erosive-atrophic oral lichen planus: A pilot study\",\"authors\":\"Atessa Pakfetrat, Zahra Delavarian, Mahshid Malakooti, Hossein Bagheri, Habibollah Esmaily, Mahsa Ghorbani, Pooya Saeedi\",\"doi\":\"10.1002/cre2.886\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This study evaluates the efficacy of a novel mucoadhesive patch containing <i>Nigella sativa</i> 10% extract compared to triamcinolone 0.1% in alleviating symptoms and reducing lesion severity in patients with erosive-atrophic oral lichen planus.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods and Materials</h3>\\n \\n <p>A pilot study comprising two groups, each with 10 patients, was conducted. The intervention group received mucoadhesive patches containing <i>N. sativa</i> 10% extract, while the control group received triamcinolone acetonide 0.1% patches. Pain and burning intensity, measured through visual analog scale, and lesion severity based on the Thongprasom scale were assessed weekly for 4 weeks. Descriptive records were kept for side effects and patient satisfaction.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Pain and burning intensity decreased in both groups throughout the sessions, with the <i>N. sativa</i> group showing a greater reduction than the triamcinolone group. The reduction in burning intensity within each group was significant (<i>p</i> < .001), and there was a significant difference between groups only in the second session (<i>p</i> = .045). The overall difference between groups was not significant (<i>p</i> > .05). Lesion severity also decreased significantly in both groups (<i>p</i> < .001), with a significant difference between groups observed in the third session (<i>p</i> = .043) and overall throughout the study (<i>p</i> = .006).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The use of <i>N. sativa</i> extract in mucoadhesive patches was as effective as corticosteroids in reducing pain, burning, and lesion severity in patients with oral lichen planus, with <i>N. sativa</i> showing superior results in some sessions. Notably, no significant complications were observed with <i>N. sativa</i> use, making it a promising treatment option for lichen planus.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10203,\"journal\":{\"name\":\"Clinical and Experimental Dental Research\",\"volume\":\"10 3\",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-05-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.886\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Dental Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cre2.886\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Dental Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cre2.886","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Comparing the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% with triamcinolone 0.1% in patients with erosive-atrophic oral lichen planus: A pilot study
Objective
This study evaluates the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% extract compared to triamcinolone 0.1% in alleviating symptoms and reducing lesion severity in patients with erosive-atrophic oral lichen planus.
Methods and Materials
A pilot study comprising two groups, each with 10 patients, was conducted. The intervention group received mucoadhesive patches containing N. sativa 10% extract, while the control group received triamcinolone acetonide 0.1% patches. Pain and burning intensity, measured through visual analog scale, and lesion severity based on the Thongprasom scale were assessed weekly for 4 weeks. Descriptive records were kept for side effects and patient satisfaction.
Results
Pain and burning intensity decreased in both groups throughout the sessions, with the N. sativa group showing a greater reduction than the triamcinolone group. The reduction in burning intensity within each group was significant (p < .001), and there was a significant difference between groups only in the second session (p = .045). The overall difference between groups was not significant (p > .05). Lesion severity also decreased significantly in both groups (p < .001), with a significant difference between groups observed in the third session (p = .043) and overall throughout the study (p = .006).
Conclusion
The use of N. sativa extract in mucoadhesive patches was as effective as corticosteroids in reducing pain, burning, and lesion severity in patients with oral lichen planus, with N. sativa showing superior results in some sessions. Notably, no significant complications were observed with N. sativa use, making it a promising treatment option for lichen planus.
期刊介绍：
Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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