病灶脉络膜切除并发脉络膜视网膜疾病的风险因素：通过 SD-OCT 进行评估

IF 3.2 Q1 OPHTHALMOLOGY

Ophthalmology science Pub Date : 2024-05-22 DOI:10.1016/j.xops.2024.100554

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Parameters of FCE identified using spectral-domain OCT (SD-OCT) were manually measured using built-in software and subsequently analyzed statistically.</p></div><div><h3>Main Outcome Measures</h3><p>Subfoveal choroidal thickness (SFCT), subexcavation choroidal thickness (SECT), and the greatest depth and width of each excavation were manually measured using built-in calipers in OCT software.</p></div><div><h3>Results</h3><p>Twenty-one patients (13/8, male/female) with FCE were included in this study. The average age was 45.2 years, and their best-corrected visual acuity (BCVA) was 0.4 logarithm of the minimum angle of resolution (Snellen equivalent, 20/50). Focal choroidal excavation was present in 28 eyes of 21 patients, including isolated FCE (12 eyes) and complicated FCE (16 eyes) with choroidal neovascularization (sCNV), central serous chorioretinopathy, and other conditions. Patients with complicated FCE were significantly older than those isolated FCE (<em>P</em> = 0.015). 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引用次数: 0

摘要

目的探讨局灶性脉络膜挖损（FCE）患者的风险因素及其与脉络膜视网膜疾病的相关性。方法收集人口统计学信息、临床特征和多模态图像。主要结果测量使用 OCT 软件中的内置卡尺手动测量脉络膜下厚度（SFCT）、脉络膜下挖空厚度（SECT）以及每个挖空的最大深度和宽度。结果21 名 FCE 患者（13/8，男性/女性）被纳入本研究。他们的平均年龄为 45.2 岁，最佳矫正视力（BCVA）为最小分辨角的 0.4 对数（斯奈伦等效视力，20/50）。21 名患者中有 28 只眼睛存在局灶性脉络膜挖出，其中包括孤立性 FCE（12 只眼睛）和伴有脉络膜新生血管（sCNV）、中心性浆液性脉络膜视网膜病变及其他情况的复杂性 FCE（16 只眼睛）。复杂性 FCE 患者的年龄明显大于孤立性 FCE 患者（P = 0.015）。健康受试者的 SFCT 明显小于 FCE 患者同侧眼的 SFCT（P < 0.01），孤立性 FCE（P < 0.001）和复杂性 FCE（P < 0.001）患者同侧眼的 SFCT 也是如此。复杂性 FCE 眼球的挖掘宽度比孤立性 FCE 眼球的挖掘宽度大（P = 0.001）。结论局灶性脉络膜挖空似乎与脉络膜视网膜疾病密切相关，挖空的宽度是评估脉络膜视网膜疾病风险的重要指标。

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Risk Factors for Focal Choroidal Excavation Concurrent with Chorioretinal Disease: Evaluated by Spectral-Domain OCT

Purpose

To investigate the risk factors for patients with focal choroidal excavation (FCE) and their correlation with chorioretinal diseases.

Design

Retrospective cross-sectional study.

Subjects

Patients with FCE were enrolled, while healthy subjects were recruited for the control group.

Methods

The study collected demographic information, clinical features, and multimodal images. Parameters of FCE identified using spectral-domain OCT (SD-OCT) were manually measured using built-in software and subsequently analyzed statistically.

Main Outcome Measures

Subfoveal choroidal thickness (SFCT), subexcavation choroidal thickness (SECT), and the greatest depth and width of each excavation were manually measured using built-in calipers in OCT software.

Results

Twenty-one patients (13/8, male/female) with FCE were included in this study. The average age was 45.2 years, and their best-corrected visual acuity (BCVA) was 0.4 logarithm of the minimum angle of resolution (Snellen equivalent, 20/50). Focal choroidal excavation was present in 28 eyes of 21 patients, including isolated FCE (12 eyes) and complicated FCE (16 eyes) with choroidal neovascularization (sCNV), central serous chorioretinopathy, and other conditions. Patients with complicated FCE were significantly older than those isolated FCE (P = 0.015). The SFCT of the healthy subjects was significantly less than that of the fellow eyes of the patients with FCE (P < 0.01), as was that of the eyes with isolated FCE (P < 0.001) and complicated FCE (P < 0.001). The width of excavation was wider in eyes with complicated FCE than in those with isolated FCE (P = 0.001). Hypertransmission defect (HD) was found beneath 15 excavations and was more prevalent in the complicated FCE group than the isolated FCE group (P = 0.023).

Conclusions

Focal choroidal excavation appears to be closely related to chorioretinal disorders, and the width of the excavation is a significant indicator for evaluating the risk of chorioretinal diseases.