骨软骨界面工程学的挑战和最新进展

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Rachel C. Nordberg , Deborah H. Wen , Dean Wang , Jerry C. Hu , Kyriacos A. Athanasiou
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引用次数: 0

摘要

由于病灶缺损和骨关节炎等软骨相关病症的发病率很高,因此需要制定策略来恢复骨软骨组织的结构和功能。关节软骨和骨具有截然不同的特性,因此,要在工程学上设计出一个可减少应力集中和分层的坚固界面,具有很大的挑战性。骨软骨界面由蒂痕、钙化软骨、骨水泥线和周围组织组成,具有独特的结构和功能,但目前还缺乏定量数据对其进行描述。通过表征阐明结构与功能的关系对于确定组织工程的设计标准至关重要。骨软骨工程采用了基于支架的方法,例如将聚合物与陶瓷结合使用。令人兴奋的是,无支架方法正在用于关节软骨层的工程,这种方法可以与下层骨基质连接。关键的目标必须是设计出一种界面,使其显示出足以承受本地环境的强大力学性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Challenges and recent advances in engineering the osteochondral interface

Due to the high incidence of cartilage-related pathologies such as focal defects and osteoarthritis, strategies are needed to restore the structure and function of osteochondral tissue. Articular cartilage and bone have distinctly different properties, rendering challenging the engineering of a robust interface that reduces stress concentrations and delamination. The osteochondral interface, which consists of a tidemark, calcified cartilage, cement line, and surrounding tissues, has a unique structure and function, but there is a dearth of quantitative data to describe it. Elucidating the structure–function relationships through characterization will be essential in defining design criteria for tissue engineering. Osteochondral engineering has used scaffold-based methods that, for example, use polymers in conjunction with ceramics. Excitingly, scaffold-free methods are emerging for engineering the articular cartilage layer, which can be interfaced with an underlying bone substrate. Critical must be the objective of designing an interface that displays mechanics robust enough to withstand the native environment.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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