复杂淋巴异常：分子结构和医疗管理

IF 1.4 3区医学 Q3 PEDIATRICS

Seminars in Pediatric Surgery Pub Date : 2024-06-01 DOI:10.1016/j.sempedsurg.2024.151422

Alexandra J. Borst , Allison Britt , Denise M. Adams

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引用次数: 0

摘要

淋巴系统是人体最重要、最复杂的系统之一。影响淋巴系统发育或功能的疾病可导致多系统并发症和终身发病。过去二十年来，我们在淋巴系统的基础生物学和功能、淋巴发育的分子调控因子以及与淋巴管功能紊乱相关的疾病描述方面取得了显著进展。在本章中，我们将介绍复杂淋巴异常的临床特征、这些疾病驱动因素的新分子知识以及治疗淋巴疾病的新型发育疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Complex lymphatic anomalies: Molecular landscape and medical management

The lymphatic system is one of the most essential and complex systems in the human body. Disorders that affect the development or function of the lymphatic system can lead to multi-system complications and life-long morbidity. The past two decades have seen remarkable progress in our knowledge of the basic biology and function of the lymphatic system, the molecular regulators of lymphatic development, and description of disorders associated with disrupted lymphangiogensis. In this chapter we will touch on the clinical features of complex lymphatic anomalies, new molecular knowledge of the drivers of these disorders, and novel developmental therapeutics for lymphatic disease.

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来源期刊

Seminars in Pediatric Surgery PEDIATRICS-SURGERY

CiteScore

2.80

自引率

5.90%

发文量

审稿时长

>12 weeks

期刊介绍： Seminars in Pediatric Surgery provides current state-of-the-art reviews of subjects of interest to those charged with the surgical care of young patients. Each bimontly issue addresses a single topic with articles written by the experts in the field. Guest editors, all noted authorities, prepare each issue.