{"title":"更年期妇女服用大豆异黄酮对更年期症状和生活质量的影响：随机对照试验的系统回顾和元分析","authors":"Nuran GENÇTÜRK , Fatma Şule BİLGİÇ , Hülya Ulaşlı KABAN","doi":"10.1016/j.explore.2024.05.010","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This systematic review and meta-analysis aimed to examine the effect of soy isoflavones on menopausal symptoms and quality of life in climacteric women.</p></div><div><h3>Method</h3><p>The literature search was conducted in PubMed, CINAHL, Scopus, and Science Citation Index (Web of Science) until September 2023. This study is based on the recommendations of the Cochrane guidelines. The data were analysed using the Review Manager computer software (Version 5.4). The methodological quality of the studies was assessed with the RoB-2 tool.</p></div><div><h3>Results</h3><p>This analysis was completed with five studies and 425 climacteric women. According to the results of the analysis, menopausal symptoms (SMD: −0.49, 95 % CI: −1.13 to 0.16, <em>Z</em> = 1.47, <em>p</em> = 0.14), physical component (MD: −1.10, 95 % CI: −4.22 to 2.01, <em>Z</em> = 0.70, <em>p</em> = 0. 49) and mental component (MD: 0.81, 95 % CI: −6.73 to 8.35, <em>Z</em> = 0.21, <em>p</em> = 0.83), but there was a significant difference in depression level (SMD: −0.41, 95 % CI: −0.73 to −0.09, <em>Z</em> = 2.53, <em>p</em> = 0.01).</p></div><div><h3>Conclusion</h3><p>According to the results of the analysis, soy isoflavones had no effect on menopausal symptoms (vasomotor, psychosocial, physical, sexual, and urogenital complaints) and quality of life in climacteric women but did reduce the level of depression. There was a high risk of conflict of interest in the included studies.</p></div><div><h3>PROSPERO database</h3><p>Registration: CRD420234479700.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of soy isoflavones given to women in the climacteric period on menopausal symptoms and quality of life: Systematic review and meta-analysis of randomized controlled trials\",\"authors\":\"Nuran GENÇTÜRK , Fatma Şule BİLGİÇ , Hülya Ulaşlı KABAN\",\"doi\":\"10.1016/j.explore.2024.05.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>This systematic review and meta-analysis aimed to examine the effect of soy isoflavones on menopausal symptoms and quality of life in climacteric women.</p></div><div><h3>Method</h3><p>The literature search was conducted in PubMed, CINAHL, Scopus, and Science Citation Index (Web of Science) until September 2023. This study is based on the recommendations of the Cochrane guidelines. The data were analysed using the Review Manager computer software (Version 5.4). The methodological quality of the studies was assessed with the RoB-2 tool.</p></div><div><h3>Results</h3><p>This analysis was completed with five studies and 425 climacteric women. According to the results of the analysis, menopausal symptoms (SMD: −0.49, 95 % CI: −1.13 to 0.16, <em>Z</em> = 1.47, <em>p</em> = 0.14), physical component (MD: −1.10, 95 % CI: −4.22 to 2.01, <em>Z</em> = 0.70, <em>p</em> = 0. 49) and mental component (MD: 0.81, 95 % CI: −6.73 to 8.35, <em>Z</em> = 0.21, <em>p</em> = 0.83), but there was a significant difference in depression level (SMD: −0.41, 95 % CI: −0.73 to −0.09, <em>Z</em> = 2.53, <em>p</em> = 0.01).</p></div><div><h3>Conclusion</h3><p>According to the results of the analysis, soy isoflavones had no effect on menopausal symptoms (vasomotor, psychosocial, physical, sexual, and urogenital complaints) and quality of life in climacteric women but did reduce the level of depression. There was a high risk of conflict of interest in the included studies.</p></div><div><h3>PROSPERO database</h3><p>Registration: CRD420234479700.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-05-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1550830724000922\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1550830724000922","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
目的本系统综述和荟萃分析旨在研究大豆异黄酮对更年期症状和更年期女性生活质量的影响。方法在PubMed、CINAHL、Scopus和科学引文索引（Web of Science）中进行文献检索，直至2023年9月。本研究基于 Cochrane 指南的建议。数据使用 Review Manager 计算机软件（5.4 版）进行分析。采用 RoB-2 工具对研究的方法学质量进行了评估。分析结果显示，更年期症状（SMD：-0.49，95 % CI：-1.13 至 0.16，Z = 1.47，P = 0.14）、身体部分（MD：-1.10，95 % CI：-4.22 至 2.01, Z = 0.70, p = 0. 49）和精神部分（MD：0.81, 95 % CI：-6.73 to 8.35, Z = 0.21, p = 0.83），但抑郁水平存在显著差异（SMD：-0.结论根据分析结果，大豆异黄酮对更年期症状（血管运动、社会心理、身体、性和泌尿生殖系统不适）和更年期妇女的生活质量没有影响，但能降低抑郁水平。所纳入的研究存在较高的利益冲突风险：CRD420234479700。
The effect of soy isoflavones given to women in the climacteric period on menopausal symptoms and quality of life: Systematic review and meta-analysis of randomized controlled trials
Objective
This systematic review and meta-analysis aimed to examine the effect of soy isoflavones on menopausal symptoms and quality of life in climacteric women.
Method
The literature search was conducted in PubMed, CINAHL, Scopus, and Science Citation Index (Web of Science) until September 2023. This study is based on the recommendations of the Cochrane guidelines. The data were analysed using the Review Manager computer software (Version 5.4). The methodological quality of the studies was assessed with the RoB-2 tool.
Results
This analysis was completed with five studies and 425 climacteric women. According to the results of the analysis, menopausal symptoms (SMD: −0.49, 95 % CI: −1.13 to 0.16, Z = 1.47, p = 0.14), physical component (MD: −1.10, 95 % CI: −4.22 to 2.01, Z = 0.70, p = 0. 49) and mental component (MD: 0.81, 95 % CI: −6.73 to 8.35, Z = 0.21, p = 0.83), but there was a significant difference in depression level (SMD: −0.41, 95 % CI: −0.73 to −0.09, Z = 2.53, p = 0.01).
Conclusion
According to the results of the analysis, soy isoflavones had no effect on menopausal symptoms (vasomotor, psychosocial, physical, sexual, and urogenital complaints) and quality of life in climacteric women but did reduce the level of depression. There was a high risk of conflict of interest in the included studies.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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