Lauren Tice , Joseph Hersey , Surya Karla , Mirco Sorci , Joel Plawsky , Sal Giglia , Georges Belfort
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Impact of pH, ionic strength, and operating conditions on capture mechanisms in nanoparticle filtration
Filtration of biopharmaceutical streams can be complex due to the variety of components in the stream and their interactions among themselves and with the filter pore surfaces. This work used a variety of measurements to study the filtration of model silica nanoparticles through asymmetric hydrophilized polyethersulfone (mPES) membrane in solutions covering a range of pH and ionic strengths. Measurements included particle size, particle concentration, zeta potential, particle-particle and particle-membrane surface intermolecular forces. These measurements were used to rationalize observed particle capture behavior under various filtration conditions. We found that increasing ionic strength and decreasing pH resulted in higher particle aggregation and higher particle retention due to adsorption of model silica nanoparticles to the membrane and sieving of aggregates within the membrane. In addition, captured particles can be eluted from the membrane in some cases, depending on the operating conditions, extent of particle loading, buffer flush pressure, and buffer pH and conductivity conditions. These findings provide insight into methods to improve filtration performance and particle capture or release, including product recovery, in filtration processes.
期刊介绍:
The Journal of Membrane Science is a publication that focuses on membrane systems and is aimed at academic and industrial chemists, chemical engineers, materials scientists, and membranologists. It publishes original research and reviews on various aspects of membrane transport, membrane formation/structure, fouling, module/process design, and processes/applications. The journal primarily focuses on the structure, function, and performance of non-biological membranes but also includes papers that relate to biological membranes. The Journal of Membrane Science publishes Full Text Papers, State-of-the-Art Reviews, Letters to the Editor, and Perspectives.