使用化学美发产品与表观遗传年龄之间的关系:姐妹研究的结果

IF 3.3 Q2 ENVIRONMENTAL SCIENCES
Che-Jung Chang, Katie M. O’Brien, J. Kresovich, J. Nwanaji-Enwerem, Zongli Xu, S. Gaston, Chandra L. Jackson, Dale P. Sandler, Jack A. Taylor, Alexandra J White
{"title":"使用化学美发产品与表观遗传年龄之间的关系:姐妹研究的结果","authors":"Che-Jung Chang, Katie M. O’Brien, J. Kresovich, J. Nwanaji-Enwerem, Zongli Xu, S. Gaston, Chandra L. Jackson, Dale P. Sandler, Jack A. Taylor, Alexandra J White","doi":"10.1097/EE9.0000000000000311","DOIUrl":null,"url":null,"abstract":"Background: Hair products may be a source of harmful chemicals and have been linked to age-related health outcomes. We investigated whether the use of hair products is related to epigenetic age in a sample of Black (both Hispanic and non-Hispanic) and non-Hispanic White women. Methods: In a subset of 4358 participants aged 35–74 years from the Sister Study, we estimated cross-sectional associations between self-reported use of four chemical hair products (permanent dye, semipermanent dye, straighteners/relaxers, and hair permanents/body waves) in the year before enrollment (2003–2009) and three DNA methylation-based measures of epigenetic age (DunedinPACE, GrimAge age acceleration [GrimAgeAccel], and PhenoAge age acceleration [PhenoAgeAccel]) using survey-weighted multivariable linear regressions. Associations were estimated both overall and by self-identified race and ethnicity, adjusting for chronological age, socioeconomic and lifestyle factors, body mass index, menopausal status, and DNA methylation platform. Results: Associations between the use of hair products and the three epigenetic age measures were largely null. Use of hair permanents/body waves was modestly associated with higher DunedinPACE among all participants (βever-never = 0.010; 95% confidence interval [CI] = 0.001, 0.019) and with lower PhenoAgeAccel among Black women (βever-never = −1.53; 95% CI = −2.84, −0.21). Conclusion: In this US-based study, we found little evidence of associations between chemical hair product use and epigenetic age in Black and non-Hispanic White women. Observed associations were modest and largely not supported by dose–response relationships or were inconsistent across epigenetic age measures. Previously observed associations between chemical hair product use and aging-related health outcomes may not be explained by the biological aging pathways captured by DunedinPACE, GrimAgeAccel, or PhenoAgeAccel. Alternative biological pathways are worth investigating in racially diverse samples.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Associations between use of chemical hair products and epigenetic age: Findings from the Sister Study\",\"authors\":\"Che-Jung Chang, Katie M. O’Brien, J. Kresovich, J. Nwanaji-Enwerem, Zongli Xu, S. Gaston, Chandra L. Jackson, Dale P. Sandler, Jack A. Taylor, Alexandra J White\",\"doi\":\"10.1097/EE9.0000000000000311\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Hair products may be a source of harmful chemicals and have been linked to age-related health outcomes. We investigated whether the use of hair products is related to epigenetic age in a sample of Black (both Hispanic and non-Hispanic) and non-Hispanic White women. Methods: In a subset of 4358 participants aged 35–74 years from the Sister Study, we estimated cross-sectional associations between self-reported use of four chemical hair products (permanent dye, semipermanent dye, straighteners/relaxers, and hair permanents/body waves) in the year before enrollment (2003–2009) and three DNA methylation-based measures of epigenetic age (DunedinPACE, GrimAge age acceleration [GrimAgeAccel], and PhenoAge age acceleration [PhenoAgeAccel]) using survey-weighted multivariable linear regressions. Associations were estimated both overall and by self-identified race and ethnicity, adjusting for chronological age, socioeconomic and lifestyle factors, body mass index, menopausal status, and DNA methylation platform. Results: Associations between the use of hair products and the three epigenetic age measures were largely null. Use of hair permanents/body waves was modestly associated with higher DunedinPACE among all participants (βever-never = 0.010; 95% confidence interval [CI] = 0.001, 0.019) and with lower PhenoAgeAccel among Black women (βever-never = −1.53; 95% CI = −2.84, −0.21). Conclusion: In this US-based study, we found little evidence of associations between chemical hair product use and epigenetic age in Black and non-Hispanic White women. Observed associations were modest and largely not supported by dose–response relationships or were inconsistent across epigenetic age measures. Previously observed associations between chemical hair product use and aging-related health outcomes may not be explained by the biological aging pathways captured by DunedinPACE, GrimAgeAccel, or PhenoAgeAccel. Alternative biological pathways are worth investigating in racially diverse samples.\",\"PeriodicalId\":11713,\"journal\":{\"name\":\"Environmental Epidemiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-05-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Epidemiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/EE9.0000000000000311\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/EE9.0000000000000311","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

背景:美发产品可能是有害化学物质的来源,并与年龄相关的健康结果有关。我们调查了黑人(包括西班牙裔和非西班牙裔)和非西班牙裔白人女性样本中使用美发产品是否与表观遗传年龄有关。研究方法在 "姐妹研究"(Sister Study)的 4358 名 35-74 岁参与者中,我们估算了自我报告的四种化学发制品(永久性染发剂、半永久性染发剂、直发器/松发器和永久性发质/体波)使用情况之间的横截面关联、使用调查加权多变量线性回归,我们估算了入学前一年(2003-2009 年)使用四种化学发质产品(永久性染发剂、半永久性染发剂、直发器/松发器和永久性发质/体波)与三种基于 DNA 甲基化的表观遗传年龄测量方法(DunedinPACE、GrimAge 年龄加速 [GrimAgeAccel] 和 PhenoAge 年龄加速 [PhenoAgeAccel])之间的关系。在对实际年龄、社会经济和生活方式因素、体重指数、绝经状态和 DNA 甲基化平台进行调整后,估算了总体相关性以及自我认同的种族和民族相关性。研究结果使用美发产品与三种表观遗传年龄测量之间的关系基本为空。在所有参与者中,使用永发剂/体波与较高的 DunedinPACE 略有关联(βever-never = 0.010; 95% 置信区间 [CI] = 0.001, 0.019),而在黑人女性中,使用永发剂/体波与较低的 PhenoAgeAccel 略有关联(βever-never = -1.53; 95% CI = -2.84, -0.21)。结论在这项基于美国的研究中,我们几乎没有发现黑人和非西班牙裔白人女性使用化学发制品与表观遗传年龄之间存在关联的证据。观察到的关联不大,而且基本上没有得到剂量反应关系的支持,或者在不同的表观遗传年龄测量中不一致。之前观察到的化学发制品使用与衰老相关健康结果之间的关联可能无法用 DunedinPACE、GrimAgeAccel 或 PhenoAgeAccel 所捕获的生物衰老途径来解释。值得在不同种族的样本中研究其他生物途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between use of chemical hair products and epigenetic age: Findings from the Sister Study
Background: Hair products may be a source of harmful chemicals and have been linked to age-related health outcomes. We investigated whether the use of hair products is related to epigenetic age in a sample of Black (both Hispanic and non-Hispanic) and non-Hispanic White women. Methods: In a subset of 4358 participants aged 35–74 years from the Sister Study, we estimated cross-sectional associations between self-reported use of four chemical hair products (permanent dye, semipermanent dye, straighteners/relaxers, and hair permanents/body waves) in the year before enrollment (2003–2009) and three DNA methylation-based measures of epigenetic age (DunedinPACE, GrimAge age acceleration [GrimAgeAccel], and PhenoAge age acceleration [PhenoAgeAccel]) using survey-weighted multivariable linear regressions. Associations were estimated both overall and by self-identified race and ethnicity, adjusting for chronological age, socioeconomic and lifestyle factors, body mass index, menopausal status, and DNA methylation platform. Results: Associations between the use of hair products and the three epigenetic age measures were largely null. Use of hair permanents/body waves was modestly associated with higher DunedinPACE among all participants (βever-never = 0.010; 95% confidence interval [CI] = 0.001, 0.019) and with lower PhenoAgeAccel among Black women (βever-never = −1.53; 95% CI = −2.84, −0.21). Conclusion: In this US-based study, we found little evidence of associations between chemical hair product use and epigenetic age in Black and non-Hispanic White women. Observed associations were modest and largely not supported by dose–response relationships or were inconsistent across epigenetic age measures. Previously observed associations between chemical hair product use and aging-related health outcomes may not be explained by the biological aging pathways captured by DunedinPACE, GrimAgeAccel, or PhenoAgeAccel. Alternative biological pathways are worth investigating in racially diverse samples.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Environmental Epidemiology
Environmental Epidemiology Medicine-Public Health, Environmental and Occupational Health
CiteScore
5.70
自引率
2.80%
发文量
71
审稿时长
25 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信