B. Mary Dayana, J. Thomas Joseph Prakash, Jothi Vinoth Kumar, Merum Dhananjaya, Sang Woo Joo, Mir Waqas Alam
{"title":"溶液-凝胶法合成银纳米粒子,利用鸦胆子提取物提高抗菌、抗氧化、抗真菌和抗癌活性","authors":"B. Mary Dayana, J. Thomas Joseph Prakash, Jothi Vinoth Kumar, Merum Dhananjaya, Sang Woo Joo, Mir Waqas Alam","doi":"10.1007/s10971-024-06409-6","DOIUrl":null,"url":null,"abstract":"<div><p>The distinctive biological properties exhibited by silver nanoparticles (AgNPs) have propelled this material to the forefront of biological property candidates. Solution-gelation synthesis emerges as a highly promising method among preparation techniques to compensate for the shortcomings inherent in both chemical and physical approaches. The objective of this investigation was to synthesize JT-AgNPs utilizing <i>Justicia tranquebariensis</i> (JT) extract as a stabilizing and reducing agent and AgNO<sub>3</sub> solution as the Ag precursor. The obtained JT-AgNPs underwent physicochemical characterization employing various analytical techniques. In XRD analysis revealed the crystal structure of the JT-AgNPs. The JT-AgNPs with a spherical shape were identified through TEM, and exhibit a size in 22.3 nm. The zeta potential value of −21.6 mV indicates excellent stability for green synthesized JT-Ag NPs. The antibacterial activity of synthesized JT-AgNPs was assessed. When compared to the plant extract, JT-AgNPs exhibit effective inhibition of fungal strains, at a dosage of 10 µL/mL. The antioxidant properties of JT-AgNPs showed a proton radical scavenging efficiency of 77.64% at 100 µg/mL (IC<sub>50</sub> value of 44.41 µg/mL). At a concentration of 15 µg/mL, the synthesized JT-AgNPs demonstrated remarkable efficacy against MDA-MB-231 cancer cells, (IC<sub>50</sub> value of 11.02 µg/mL). These results suggest a promising future herbal medication in nanomaterials form.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":664,"journal":{"name":"Journal of Sol-Gel Science and Technology","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solution-gelation synthesis of silver nanoparticles utilizing Justicia tranquebariensis extract for antibacterial, antioxidant, antifungal and anticancer activity\",\"authors\":\"B. Mary Dayana, J. Thomas Joseph Prakash, Jothi Vinoth Kumar, Merum Dhananjaya, Sang Woo Joo, Mir Waqas Alam\",\"doi\":\"10.1007/s10971-024-06409-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The distinctive biological properties exhibited by silver nanoparticles (AgNPs) have propelled this material to the forefront of biological property candidates. Solution-gelation synthesis emerges as a highly promising method among preparation techniques to compensate for the shortcomings inherent in both chemical and physical approaches. The objective of this investigation was to synthesize JT-AgNPs utilizing <i>Justicia tranquebariensis</i> (JT) extract as a stabilizing and reducing agent and AgNO<sub>3</sub> solution as the Ag precursor. The obtained JT-AgNPs underwent physicochemical characterization employing various analytical techniques. In XRD analysis revealed the crystal structure of the JT-AgNPs. The JT-AgNPs with a spherical shape were identified through TEM, and exhibit a size in 22.3 nm. The zeta potential value of −21.6 mV indicates excellent stability for green synthesized JT-Ag NPs. The antibacterial activity of synthesized JT-AgNPs was assessed. When compared to the plant extract, JT-AgNPs exhibit effective inhibition of fungal strains, at a dosage of 10 µL/mL. The antioxidant properties of JT-AgNPs showed a proton radical scavenging efficiency of 77.64% at 100 µg/mL (IC<sub>50</sub> value of 44.41 µg/mL). At a concentration of 15 µg/mL, the synthesized JT-AgNPs demonstrated remarkable efficacy against MDA-MB-231 cancer cells, (IC<sub>50</sub> value of 11.02 µg/mL). 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Solution-gelation synthesis of silver nanoparticles utilizing Justicia tranquebariensis extract for antibacterial, antioxidant, antifungal and anticancer activity
The distinctive biological properties exhibited by silver nanoparticles (AgNPs) have propelled this material to the forefront of biological property candidates. Solution-gelation synthesis emerges as a highly promising method among preparation techniques to compensate for the shortcomings inherent in both chemical and physical approaches. The objective of this investigation was to synthesize JT-AgNPs utilizing Justicia tranquebariensis (JT) extract as a stabilizing and reducing agent and AgNO3 solution as the Ag precursor. The obtained JT-AgNPs underwent physicochemical characterization employing various analytical techniques. In XRD analysis revealed the crystal structure of the JT-AgNPs. The JT-AgNPs with a spherical shape were identified through TEM, and exhibit a size in 22.3 nm. The zeta potential value of −21.6 mV indicates excellent stability for green synthesized JT-Ag NPs. The antibacterial activity of synthesized JT-AgNPs was assessed. When compared to the plant extract, JT-AgNPs exhibit effective inhibition of fungal strains, at a dosage of 10 µL/mL. The antioxidant properties of JT-AgNPs showed a proton radical scavenging efficiency of 77.64% at 100 µg/mL (IC50 value of 44.41 µg/mL). At a concentration of 15 µg/mL, the synthesized JT-AgNPs demonstrated remarkable efficacy against MDA-MB-231 cancer cells, (IC50 value of 11.02 µg/mL). These results suggest a promising future herbal medication in nanomaterials form.
期刊介绍:
The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.